Elias S.J. Arnér

This study identifies GPX3 as a paracrine mediator of adipose tissue insulin sensitivity through a GPX3-SP1-InsR signaling axis, independent of its peroxidase activity.

This study shows sodium aurothiomalate induces ferroptosis by covalently modifying GPX4 through a gold-dependent mechanism, leading to tumor growth reduction in preclinical models.

The paper shows that inactivating the NMD pathway suppresses the embryonic lethality of gsr-1 mutants in C. elegans by enabling the transsulfuration pathway to compensate for the loss of glutathione reductase function.

The paper reconstructs and assays ancient enzymes to show that losing selenocysteine in GPX6 led to functional loss and convergent evolution in mammalian oxidoreductases.