Author

David J. Shirley

University of North Carolina at Chapel HillORCID 0009-0003-2475-7366Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

Bonnie YiuiD· 2 shared David Harold DrewryiD· 2 shared Leah E. CoweniD· 2 shared Luke J. WhiteselliD· 2 shared Nicole RobbinsiD· 2 shared Timothy Mark WillsoniD· 2 shared Zhongle LiuiD· 2 shared Angie L. MordantiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Bonnie YiuORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintJul 12, 2025

Structure-activity Relationship for Diarylpyrazoles as Inhibitors of the Fungal Kinase Yck2

David J. Shirley, Bonnie Yiu, Ikeer Y. Mancera-Ortiz…·Timothy Mark Willson

The paper identifies structure-activity relationships for diarylpyrazole inhibitors of the fungal kinase Yck2, showing improved selectivity and antifungal activity.

DOI 10.1101/2025.07.12.664496

yeastexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintJan 10, 2025

Chemoproteomic Profiling of C. albicans for Characterization of Anti-fungal Kinase Inhibitors

David J. Shirley, Meganathan Nandakumar, Aurora Cabrera…·Timothy Mark Willson

The paper uses chemoproteomic profiling to identify selective anti-fungal kinase inhibitors targeting C. albicans CK1 homologs.

DOI 10.1101/2025.01.10.632200

C. elegansproteomics

𝕏 PostBluesky