Author
University of TorontoORCID 0000-0003-2821-9269Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Kirsten J. Meyer, Valerie Chow, Elaina Piliouras…·Justin Rea Nodwell
This study identifies co-packaging of two antimicrobial compounds in extracellular vesicles, showing enhanced potency against fungal biofilms compared to individual compounds.
Xuefei Chen, H. Diessel Duan, Michael J. Hoy…·Gerard D. Wright
The paper identifies butyrolactol A as a compound that enhances caspofungin efficacy against resistant fungi by inhibiting phospholipid flippase, thereby improving antifungal treatment.
David J. Shirley, Bonnie Yiu, Ikeer Y. Mancera-Ortiz…·Timothy Mark Willson
The paper identifies structure-activity relationships for diarylpyrazole inhibitors of the fungal kinase Yck2, showing improved selectivity and antifungal activity.
Ci Fu, Nicole Robbins, Leah E. Cowen
This study adapts the tetracycline-repressible system to regulate essential gene expression in Cryptococcus neoformans, demonstrating its effectiveness in depleting HSP90 and inhibiting fungal growth.
David J. Shirley, Meganathan Nandakumar, Aurora Cabrera…·Timothy Mark Willson
The paper uses chemoproteomic profiling to identify selective anti-fungal kinase inhibitors targeting C. albicans CK1 homologs.