Author

Luke J. Whitesell

University of TorontoORCID 0000-0001-6445-5766Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:yeast· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Leah E. CoweniD· 3 shared Bonnie YiuiD· 2 shared David Harold DrewryiD· 2 shared David J. ShirleyiD· 2 shared Nicole RobbinsiD· 2 shared Timothy Mark WillsoniD· 2 shared Zhongle LiuiD· 2 shared Amanda K. LukensiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

Leah E. CowenORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintJul 12, 2025

Structure-activity Relationship for Diarylpyrazoles as Inhibitors of the Fungal Kinase Yck2

David J. Shirley, Bonnie Yiu, Ikeer Y. Mancera-Ortiz…·Timothy Mark Willson

The paper identifies structure-activity relationships for diarylpyrazole inhibitors of the fungal kinase Yck2, showing improved selectivity and antifungal activity.

DOI 10.1101/2025.07.12.664496

yeastexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintJan 10, 2025

Chemoproteomic Profiling of C. albicans for Characterization of Anti-fungal Kinase Inhibitors

David J. Shirley, Meganathan Nandakumar, Aurora Cabrera…·Timothy Mark Willson

The paper uses chemoproteomic profiling to identify selective anti-fungal kinase inhibitors targeting C. albicans CK1 homologs.

DOI 10.1101/2025.01.10.632200

C. elegansproteomics

𝕏 PostBluesky

GeneticsbioRxivPreprintFeb 17, 2021

Defining the Yeast Resistome through in vitro Evolution and Whole Genome Sequencing

Sabine Ottilie, Madeline R. Luth, Erich Hellemann…·Elizabeth A. Winzeler

The paper identifies genetic determinants of chemical resistance in yeast using in vitro evolution and whole genome sequencing, revealing key transcription factors involved in drug resistance.

4 citations

yeastwhole-genome sequencing

𝕏 PostBluesky