Author

Melissa Cunningham

Oregon Health & Science UniversityORCID 0009-0003-2851-9138Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:imaging· 2 Research Focus:development & morphogenesis· 1 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Rosalie C. SearsiD· 3 shared Jonathan Robert BrodyiD· 2 shared Katherine R. PelziD· 2 shared Patrick Joseph WorthiD· 2 shared Xiaoyan WangiD· 2 shared Amy T. Farrell· 1 shared Ashley L. KiemeniD· 1 shared Assmaa ElSheikhiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

Rosalie C. SearsORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 22, 2026

✦ In-depth digest

MYC targeted de novo binders impair tumor growth

Nora K. McNamara-Bordewick, Kejia Wu, Yulong Su…·David A. Baker

Designed protein binders to conserved MYC regions reach low-nanomolar affinity, reduce MYC-MAX proximity in cells, and are depleted from MYC-dependent cancer cells in culture and mouse pancreatic tumors.

1 citation

humanmouse

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Cancer BiologyCancer Research CommunicationsPeer-reviewedNov 24, 2025

MicroCT enables simultaneous longitudinal tracking of murine pancreatic cancer progression and cachexia

Katherine R. Pelz, Philip Jimenez, Colin J. Daniel…·Teresa A. Zimmers

This paper introduces a dual-contrast microCT protocol to track tumor growth, metastasis, and cachexia in murine PDAC models over time.

1 citation

mouseimaging

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Cancer BiologybioRxivPreprintJul 14, 2025

Myc and Kras cooperate in adult acinar cells to drive phenotypic heterogeneity, metastasis, and therapeutic resistance in a novel pancreatic cancer mouse model

Isabel A. English, Patrick Joseph Worth, Kevin Hawthorne…·Rosalie C. Sears

This study develops a novel pancreatic cancer mouse model by expressing Myc and mutant Kras in adult acinar cells, showing metastasis and therapeutic resistance similar to human PDAc.

5 citations

mouseexperimental assay

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