Defective Microhomology-Mediated End-joining in SMARCB1-Deficient Tumors
Guang‐Li Zhu, Shuhei Asada, Huy Q. Nguyen, Yuna Hirohashi, Lifang Sun, Avneesh Saravanapavan, Erfan Rahmani, Maryia Hrynashka, Sirisha Mukkavalli, Mona Batish, Geoffrey Ira Shapiro, Alan D. D’Andrea
This study identifies a defect in MMEJ repair in SMARCB1-deficient tumors, leading to hyper-dependence on the FA/BRCA pathway, which can be targeted for therapy.
Science Advances · Aug 14, 2026Peer-reviewedCancer Biology