Author

Ryan W. Rue

University of PennsylvaniaORCID 0009-0004-1608-9780Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Vera P. KrymskayaiD· 2 shared Akansha Goel· 1 shared Alexander R. MukhitoviD· 1 shared Carly J. SmithiD· 1 shared Debbie ClementsiD· 1 shared Edward CantuiD· 1 shared Edward E. MorriseyiD· 1 shared Emma L. RawlinsiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Vera P. KrymskayaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis

Roya Babaei‐Jadidi, Debbie Clements, Yixin Wu, Ken Chen, Suzanne Miller, Manuela Platé, Kyungtae Lim, Ryan W. Rue, Vera P. Krymskaya, Rachel Clare Chambers, Emma L. Rawlins, Yan Juan Xu, Simon R. Johnson

This study shows mTOR dysregulation in LAM causes IL6 production and senescence in AT2 cells, impairing lung repair, and suggests targeting IL6 may help.

Nature Communications · Oct 9, 2025Peer-reviewedCell Biology

Hyperactive mTOR in Lung Mesenchyme Induces Endothelial Dysfunction and Pulmonary Vascular Remodeling

Susan M. Lin, Ryan W. Rue, Akansha Goel, Kseniya Obraztsova, Alexander R. Mukhitov, Kanth Swaroop Vanka, Carly J. Smith, Maria Ciocca Basil, Laura T. Ferguson, Joseph D. Planer, Edward Cantu, Grażyna Kwapiszewska, Edward E. Morrisey, Jillian F. Evans, Vera P. Krymskaya

The paper investigates how hyperactive mTOR in lung mesenchyme leads to endothelial dysfunction and pulmonary vascular remodeling in LAM.

bioRxiv · Oct 8, 2022 · PreprintMolecular Biology