Swati Balakrishnan

Identification and Characterization of a Small Molecule Ligand for the Huntingtin-HAP40 Complex

The paper identifies a small molecule ligand for the HTT-HAP40 complex using AS-MS and validates its binding through multiple techniques, highlighting a druggable interface for HD therapeutics.

High-Affinity, Structure-Validated and Selective Macrocyclic Peptide Tools for Chemical Biology Studies of Huntingtin

This paper identifies and characterizes high-affinity, selective macrocyclic peptide ligands for Huntingtin, enabling structural and functional studies of HTT and its complex with HAP40.

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity

The paper identifies RADX separation of function mutants using CRISPR base editing screens, showing reduced RAD51 ATP hydrolysis activity and replication defects.