Julien George Roth

Hydrogel-imposed boundary conditions guide single-lumen neuroepithelial morphogenesis

This paper develops a hydrogel system to guide single-lumen neuroepithelial tissue formation from iPSCs, identifying matrix stress relaxation and tensional homeostasis as key regulators.

Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission

This study compares neuronal phenotypes from monozygotic twins discordant for schizophrenia, finding differences in synaptic activity and neuronal maturation between affected and unaffected siblings.

Biocompatible polymers for scalable production of human neural organoids

This paper develops a scalable neural organoid platform using biocompatible polymers to prevent fusion, enabling drug and teratogen screening with over 2,400 cortical organoids.

Copy Number Variation at 16p11.2 Imparts Transcriptional Alterations in Neural Development in an hiPSC-derived Model of Corticogenesis

The paper generates 65 hiPSC clones with 16p11.2 CNVs and identifies transcriptional changes in neural development using RNA-Seq.

Genome-wide molecular effects of the neuropsychiatric 16p11 CNVs in an iPSC-to-iN neuronal model

The paper investigates the molecular effects of 16p11.2 CNVs on gene expression and DNA methylation using an iPSC-to-iN model and identifies potential contributing genes.