Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels
Reem Handklo‐Jamal, Tal Keren Raifman, Boris Shalomov, Patrick Hofer, Uri Kahanovitch, Theres Friesacher, Galit Tabak, Vladimir Tsemakhovich, Haritha P. Reddy, Orna Chomsky-Hecht, Debi Ranjan Tripathy, Kerstin Zühlke, CARMEN W. DESSAUER, Enno Klußmann, Yoni Haitin, , Nathan Dascal
The paper shows Gβγ interacts with GIRK2 and GIRK1/2 channels with affinities in the microM range, with GIRK1/2 having higher apparent affinity due to a unique Gβγ docking site.
Nature Communications · Nov 24, 2025Peer-reviewedPhysiology