Author

Michael Witcher

Jewish General HospitalORCID 0000-0002-4466-9166Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 3 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Benjamin LebeauiD· 2 shared Josie Ursini‐SiegeliD· 2 shared Alexandra CsábiiD· 1 shared Alexandre MaréchaliD· 1 shared Alexandre OrthweiniD· 1 shared Anne BarlieriD· 1 shared Ashutosh RaiiD· 1 shared Attila PatócsiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Benjamin LebeauORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ctcf deficiency in myofibers induces pathological genome reprogramming toward the spontaneous development of myopathy

Jimmy Massenet, Chiara Nicoletti, Luca Caputo, Sören S. Hüttner, Monica M Nicolau, Jesus R Barajas, Maira Rossi, Yuqing Yang, Yu Xin Wang, Tom H. Cheung, Michael Witcher, Colin G. Crist, Prem Puri

This study shows that Ctcf deficiency in myofibers leads to genome reprogramming and myopathy by disrupting 3D genome structure and gene regulation.

bioRxiv · Oct 14, 2026 · PreprintMolecular Biology

Familial medullary thyroid carcinoma secondary to an SLC30A9 intragenic deletion and translation reinitiation

Donato Iacovazzo, Federica Begalli, Oniz Suleyman, Márton Doleschall, Maria Alevizaki, Kevin E. Ashelford, Sherine Awad Mahmoud, Anne Barlier, Sayka Barry, Caroline E Brain, Claudia Cabrera, Frédéric Castinetti, Sabrina Chiloiro, Kevin Colclough, Alexandra Csábi, , Márta Korbonits

The paper identifies an SLC30A9 deletion causing familial medullary thyroid carcinoma through translation reinitiation and shows its oncogenic effects.

medRxiv · Feb 27, 2026 · PreprintGenetic & Genomic Medicine

MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors

HaEun Kim, Benjamin Lebeau, David J. Papadopoli, Predrag Jovanović, Mariana De Sa Tavares Russo, Daina Zofija Avizonis, Masahiro Morita, Farzaneh Afzali, Josie Ursini‐Siegel, Lynne-Marie M Postovit, Michael Witcher, Ivan Topisirović

This study shows that both mTOR activation and inhibition increase H3K27me3 through distinct mechanisms, and this epigenetic change correlates with the anti-proliferative effects of mTOR inhibitors.

iScience · Feb 12, 2024Peer-reviewedMolecular Biology

POGZ modulates the DNA damage response in a HP1-dependent manner

John Heath, Estelle R. Simo‐Cheyou, Steven Findlay, Vincent Mingyi Luo, Edgar Pinedo Carpio, Jeesan Lee, Billel Djerir, Xiaoru Chen, Théo Morin, Benjamin Lebeau, Martin Karam, Halil Bagci, Damien Grapton, Josie Ursini‐Siegel, Jean‐François Côté, , Alexandre Orthwein

This study identifies POGZ as a regulator of HP1-dependent DNA repair, showing its role in homology-directed repair and its clinical relevance to White Sutton syndrome.

bioRxiv · Jun 28, 2021 · PreprintMolecular Biology