Yu Xin Wang

Ctcf deficiency in myofibers induces pathological genome reprogramming toward the spontaneous development of myopathy

This study shows that Ctcf deficiency in myofibers leads to genome reprogramming and myopathy by disrupting 3D genome structure and gene regulation.

Tumor-derived SAA1-TLR4 signaling drives tumor-to-muscle communication in pancreatic cancer cachexia

This study identifies SAA1-TLR4 signaling as a tumor-derived pathway driving muscle wasting in pancreatic cancer, showing that targeting this pathway can preserve muscle mass and improve survival without affecting tumor growth.

Patient iPSC-Derived Cartilage Organoids Reveal Defective ECM Deposition and Altered Chondrogenic Trajectory in Saul-Wilson Syndrome

This study uses patient-derived iPSC cartilage organoids to show defective ECM deposition and altered chondrogenic trajectory in Saul-Wilson syndrome.

HIRA-mediated H3.3 deposition preserves hepatocyte cell identity during liver aging

This study shows that HIRA-mediated H3.3 deposition maintains hepatocyte identity during aging, and its loss leads to metabolic dysfunction and fibrosis, which can be partially reversed by tissue regeneration.

Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer

This study shows that disabling PSGL-1 enhances anti-tumor immunity in pancreatic cancer by improving CD8+ T cell function and response to PD-1 blockade.

TLPath predicts telomere length in human tissues from histopathology images

TLPath predicts bulk-tissue telomere length from histopathology images, showing aging-related morphological changes and outperforming chronological age as a predictor.

Deep learning the cis-regulatory code of chromatin dynamics during cellular reprogramming

The paper uses deep learning to analyze chromatin accessibility and gene expression during reprogramming, revealing how TF concentrations and motif syntax influence cis-regulatory networks.

KDR Signaling in Muscle Stem Cells Promotes Asymmetric Division and Progenitor Generation for Efficient Regeneration

This study identifies KDR signaling as essential for muscle stem cell asymmetric division and progenitor generation, crucial for efficient muscle regeneration.