Author

Jia Huang

Chinese Academy of SciencesORCID 0000-0001-7629-9641Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Jia Huang3 papers · Sir Run Run Shaw Hospital

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Bingbing HeiD· 2 shared Chunlong XuiD· 2 shared Hui YangiD· 2 shared Mingxing Xue· 2 shared Xiali YangiD· 2 shared Yingsi ZhouiD· 2 shared Dingyi HaniD· 1 shared Guoling LiiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersMolecular Biology

Bingbing HeORCID

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2 papers

Recent·Most cited

High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effect

Huawei Tong, Jia Huang, Qingquan Xiao, Bingbing He, Xue Dong, Yuanhua Liu, Xiali Yang, Dingyi Han, Zikang Wang, Xuchen Wang, Wenqin Ying, Runze Zhang, Wei Yu, Chunlong Xu, Yingsi Zhou, , Hui Yang

The paper designs high-fidelity Cas13 variants with minimal collateral RNA degradation effects, validated in mammalian cells and transgenic mice.

Nature Biotechnology · Aug 11, 2022Peer-reviewedMolecular Biology

Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver

Bingbing He, Wenbo Peng, Jia Huang, Hang Zhang, Yingsi Zhou, Xiali Yang, Jing Liu, Zhijie Li, Chunlong Xu, Mingxing Xue, Hui Yang, Pengyu Huang

This study demonstrates the use of CasRx-mediated RNA knockdown to modulate metabolic genes in mouse liver, showing efficient and reversible reduction of PCSK9 and cholesterol levels.

Protein & Cell · Mar 18, 2020Peer-reviewedGenomics