Author

Amrutha Kizhedathu

Institute for Stem Cell Biology and Regenerative MedicineORCID 0009-0005-9034-1427Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:Drosophila· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Arjun GuhaiD· 2 shared Pablo Lara-GonzáleziD· 2 shared Shabnam MogharehiD· 2 shared Anh Cao Ngoc NguyeniD· 1 shared Archit V BaguliD· 1 shared Claudia A. BenaventeiD· 1 shared Clinton YuiD· 1 shared David BojorqueziD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersDevelopmental Biology

Arjun GuhaORCID

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 28, 2026

A meiotic B-type cyclin selectively drives mitotic progression and fidelity in cancer cells

Amrutha Kizhedathu, Anh Cao Ngoc Nguyen, Clinton Yu…·Pablo Lara-González

This study shows cyclin B3-CDK1/2 drives mitotic progression and fidelity in cancer cells, with overexpression accelerating mitosis and depletion disrupting it in multiple cancer models.

DOI 10.64898/2026.09.28.754947

humanstatistical model

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Developmental BiologybioRxivPreprintJul 23, 2026

Cyclin B3-CDK1 couples translational de-repression to embryonic mitoses via OMA protein degradation in C. elegans.

David Bojorquez, Shabnam Moghareh, Maab Elsayed…·Pablo Lara-González

This study shows that cyclin B3-CDK1 promotes mRNA de-repression in C. elegans embryos by degrading OMA proteins, linking mitosis to early gene expression.

DOI 10.64898/2026.07.22.740101

C. elegansbulk RNA-seq

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Developmental BiologyeLifePeer-reviewedOct 8, 2021

Duox generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts

Amrutha Kizhedathu, Piyush Chhajed, Lahari Yeramala…·Arjun Guha

The paper shows Duox-generated ROS activates ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts through a non-canonical mechanism.

9 citations

Drosophilaexperimental assay

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Developmental BiologyeLifePeer-reviewedSep 2, 2020

Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts

Amrutha Kizhedathu, Rose Sebastian Kunnappallil, Archit V Bagul…·Arjun Guha

8 citations

Drosophilaexperimental assay

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