Author

Hanchen Li

University of Massachusetts Chan Medical SchoolORCID 0009-0005-9980-028XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:protein structure· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Raffi V. AroianiD· 3 shared Alasdair J. NisbetiD· 1 shared Amanda O. ShaveriD· 1 shared Amy H. BuckiD· 1 shared Cei Abreu‐GoodgeriD· 1 shared Chanel Milène NaariD· 1 shared Clayton M. DilksiD· 1 shared Daniel R. G. PriceiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

Raffi V. AroianORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintApr 24, 2026

Chromosomal markerless integration of anthelmintic Cry proteins into the Bacillus thuringiensis genome

Kelly A. Flanagan, Nicholas R. Cazeault, Hanchen Li…·Raffi V. Aroian

This paper develops markerless integration methods for Cry proteins in Bt to enable safe and stable Cry expression for anthelmintic applications.

DOI 10.64898/2026.04.24.720002

bacteria (other)experimental assay

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Molecular BiologyEMBO ReportsPeer-reviewedDec 9, 2025

A non-vesicular Argonaute protein is transmitted from nematode to mouse and is important for parasite survival

Kyriaki Neophytou, Isaac Martínez-Ugalde, Thomas M. Fenton…·Amy H. Buck

This study identifies an extracellular Argonaute protein from a parasitic nematode that can be internalized by mouse cells and shows it can be targeted for vaccine development.

6 citationstop 3%

mouseprotein structure

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GeneticsPLoS PathogensPeer-reviewedApr 3, 2023

Variation in anthelmintic responses are driven by genetic differences among diverse C. elegans strains

Amanda O. Shaver, Janneke Wit, Clayton M. Dilks…·Erik C. Andersen

This study identifies genetic differences among C. elegans strains that drive variation in anthelmintic responses across multiple drug classes, highlighting the importance of genetic diversity in understanding anthelmintic resistance.

29 citationstop 1%

C. elegansstatistical model

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