Raffi V. Aroian

Chromosomal markerless integration of anthelmintic Cry proteins into the Bacillus thuringiensis genome

This paper develops markerless integration methods for Cry proteins in Bt to enable safe and stable Cry expression for anthelmintic applications.

Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system

The paper identifies hookworm genes upregulated by the host immune system, focusing on intestinal-expressed genes in A. ceylanicum and their potential roles in immune evasion.

A non-vesicular Argonaute protein is transmitted from nematode to mouse and is important for parasite survival

This study identifies an extracellular Argonaute protein from a parasitic nematode that can be internalized by mouse cells and shows it can be targeted for vaccine development.

High-throughput screening of more than 30,000 compounds for anthelmintics against gastrointestinal nematode parasites

This study screens over 30,000 compounds to identify new anthelmintics effective against gastrointestinal nematodes, finding 55 compounds with broad-spectrum activity.

Variation in anthelmintic responses are driven by genetic differences among diverse C. elegans strains

This study identifies genetic differences among C. elegans strains that drive variation in anthelmintic responses across multiple drug classes, highlighting the importance of genetic diversity in understanding anthelmintic resistance.