Author

Nuo Chen

Chinese University of Hong Kong, ShenzhenORCID 0009-0006-5675-8656Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein design· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Arieh WarsheliD· 1 shared Bin PangiD· 1 shared Donghai PengiD· 1 shared Hao FengiD· 1 shared Huan HeiD· 1 shared Huihui LiuiD· 1 shared Jie YangiD· 1 shared Jikai Rao· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

Arieh WarshelORCID

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2 papers

Recent·Most cited

Kinetics and Evolution-guided Design of High Fidelity CRISPR-Cas Endonucleases

Huihui Liu, Z Hong Zhou, Luowei Yuan, Bin Pang, Kun Xi, X F Li, Wenzhuo Ma, Rujuan Ti, Li Li, Nuo Chen, Yang Xu, Jie Yang, Yiping Yu, Yuchen Yang, Ruobing Ren, , Lizhe Zhu

This study designs high-fidelity CRISPR-Cas variants using a physics-driven approach combining molecular dynamics and protein language models, achieving significant improvements in fidelity with minimal experimental validation.

bioRxiv · Jul 7, 2026 · PreprintBiophysics

Base-modified nucleotides mediate immune signaling in bacteria

Zhifeng Zeng, Zeyu Hu, Ruiliang Zhao, Jikai Rao, Mario Rodríguez Mestre, Yanqiu Liu, Shunhang Liu, Hao Feng, Yu Chen, Huan He, Nuo Chen, Jinshui Zheng, Donghai Peng, Min Luo, Qunxin She, , Wenyuan Han

The paper identifies a bacterial anti-phage system that uses nucleobase modification to generate immune messengers, leading to population-level defense through infected cell death.

Science · Feb 20, 2025Peer-reviewedMicrobiology