TBX5 dosage governs ventricular cardiomyocyte maturation, specialization and dedifferentiation in vivo
Alexandra E. Giovou, Otto J. Mulleners, Rocco Caliandro, Vincent A J Warnaar, Arnie Boender, Mischa Klerk, Mathilde R. Rivaud, Diederik W.D. Kuster, Mauro Giacca, Bjarke Krogstrup Jensen, Gerard J.J. Boink, Monika M Gladka, Vincent M. Christoffels
This study shows how varying TBX5 levels in cardiomyocytes affects their maturation, specialization, and dedifferentiation, revealing a non-linear relationship with cardiac function.
bioRxiv · Apr 15, 2026 · PreprintDevelopmental Biology