Neil K. Savalia

This study shows psilocybin increases dendritic calcium activity in mice during quiet wakefulness, dependent on 5-HT2A receptors, and disrupts the link between calcium signaling and spine formation.

This study shows psilocybin selectively affects GABAergic interneurons in the mouse medial frontal cortex, reducing somatostatin-expressing and increasing parvalbumin-expressing neuron activity.

This study shows psilocybin alters large-scale cortical network connectivity in mice by strengthening inputs from perceptual and medial regions and weakening cortico-cortical loops, dependent on drug-evoked spiking activity.

This study shows that Scn2a haploinsufficiency impairs dendritic signaling and flexible decision-making in mice.

This study uses two-photon microscopy to show that NE and ACh transients have distinct spatiotemporal dynamics during decision-making in mice, with NE promoting exploration.

This study uses single-nucleus RNA sequencing to show psilocybin and ketamine induce cell type-specific and time-dependent gene expression changes in mouse medial frontal cortex neurons.

This study identifies specific pyramidal cell types and 5-HT2A receptors in the medial frontal cortex as essential for psilocybin's long-term therapeutic effects.

The paper investigates how spatiotemporal dynamics of norepinephrine release in the prefrontal cortex affect neuronal firing and finds that local NE fields can drive cell firing independently of global fields during decoupling.

This study shows psilocybin rapidly and persistently increases dendritic spine size and density in mouse frontal cortex, with lasting behavioral and neurophysiological effects.