Quan Jiang

This study shows psilocybin increases dendritic calcium activity in mice during quiet wakefulness, dependent on 5-HT2A receptors, and disrupts the link between calcium signaling and spine formation.

This study shows that C9, a component of membrane attack complexes, forms non-cytolytic intracellular aggregates that promote inflammation and EC activation through aggrephagy and NF-κB activation.

This study shows psilocybin selectively affects GABAergic interneurons in the mouse medial frontal cortex, reducing somatostatin-expressing and increasing parvalbumin-expressing neuron activity.

This study shows psilocybin alters large-scale cortical network connectivity in mice by strengthening inputs from perceptual and medial regions and weakening cortico-cortical loops, dependent on drug-evoked spiking activity.

This study identifies specific pyramidal cell types and 5-HT2A receptors in the medial frontal cortex as essential for psilocybin's long-term therapeutic effects.