Calida Mrabti

Loss of H3K9 trimethylation leads to premature aging

This study shows that loss of H3K9me3 in adult mice leads to premature aging, characterized by reduced lifespan, frailty, and accelerated epigenetic aging.

Neuron-specific partial reprogramming in the dentate gyrus impacts mouse behavior and ameliorates age-related decline in memory and learning.

This study shows that partial reprogramming of dentate gyrus neurons in mice improves memory and learning in aged animals.

Comparative analysis of mouse strains for in vivo reprogramming

This study compares mouse strains for in vivo reprogramming to develop safer strategies and create a comprehensive atlas of reprogrammable strains.

ERCC1 mice, unlike other premature aging models, display accelerated epigenetic age

The paper compares DNA methylation age in four premature aging mouse models, finding ERCC1 mice show the most significant increase in epigenetic age.

In vivo reprogramming leads to premature death due to hepatic and intestinal failure.

This study shows that continuous in vivo reprogramming with OSKM causes hepatic and intestinal failure, leading to premature death, but a new mouse strain reduces these effects.