Author

Luisa N. Segovia

California Institute of TechnologyORCID 0009-0008-5370-784XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:human· 1 Organism:non-human primate· 1

Frequent Co-Authors

Jennifer R. KeeffeiD· 3 shared Pamela J. BjörkmaniD· 3 shared Priyanthi N.P. GnanapragasamiD· 3 shared Anthony P. WestiD· 2 shared Chengcheng FaniD· 2 shared Han GaoiD· 2 shared Jaasiel Alvarez· 2 shared Kathryn E. MalecekiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Jennifer R. KeeffeORCID

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Author profile →

3 papers

Recent·Most cited

A mosaic RBD-nanoparticle pan-sarbecovirus vaccine elicits nanobodies that target highly conserved epitopes

Kathryn E. Malecek, Jennifer R. Keeffe, Chengcheng Fan, Jaasiel Alvarez, Alyssa Player, Han Gao, Priyanthi N.P. Gnanapragasam, Semi Rho, Lisa M. Schimanski, Luisa N. Segovia, Tiong Kit Tan, Pamela J. Björkman

This study identifies nanobodies targeting conserved SARS-CoV-2 RBD epitopes that neutralize variants and zoonotic sarbecoviruses.

bioRxiv · Oct 15, 2026 · PreprintImmunology

Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes

Harry B. Gristick, Harald Hartweger, Yoshiaki Nishimura, Edem Gavor, Kaito A. Nagashima, Nicholas S. Koranda, Priyanthi N.P. Gnanapragasam, Leesa M. Kakutani, Luisa N. Segovia, Olivia K. Donau, Jennifer R. Keeffe, Anthony P. West, Malcolm A. Martin, Michel C. Nussenzweig, Pamela J. Björkman

This paper designs and tests an HIV-1 vaccine candidate that targets three bNAb epitopes, showing it elicits combined immune responses in animal models.

The Journal of Experimental Medicine · Jul 11, 2025Peer-reviewedBioengineering

Cross-reactive sarbecovirus antibodies induced by mosaic RBD-nanoparticles

Chengcheng Fan, Jennifer R. Keeffe, Kathryn E. Malecek, Alexander A. Cohen, Anthony P. West, Viren A. Baharani, Annie V. Rorick, Han Gao, Priyanthi N.P. Gnanapragasam, Semi Rho, Jaasiel Alvarez, Luisa N. Segovia, Théodora Hatziioannou, Paul D. Bieniasz, Pamela J. Björkman

This paper develops mosaic RBD-nanoparticles to induce cross-reactive anti-sarbecovirus antibodies in animals, demonstrating their effectiveness against SARS-CoV-2 variants and zoonotic viruses.

Proceedings of the National Academy of Sciences · May 22, 2025Peer-reviewedImmunology