Clonal Expansion and Diversification of Germinal Center and Memory B Cell Responses to Booster Immunization in Primates
Lachlan Paul Deimel, Yoshiaki Nishimura, Gabriela S. Silva Santos, Viren A. Baharani, Brianna Hernandez, Thiago Y. Oliveira, Andrew J. MacLean, Marie Canis, Sadman Shawraz, Anna Gazumyan, Harald Hartweger, Paul D. Bieniasz, Théodora Hatziioannou, Malcolm A. Martin, Michel C. Nussenzweig
This study examines memory and germinal center B cell responses in rhesus macaques after booster immunization, finding that high affinity memory B cells form a reservoir that participates in immune development regardless of boosting site.
Cell Reports · Aug 1, 2025Peer-reviewedImmunology