Jason Vevea

Biotin-operated ligand trapping enables dynamic spatial redistribution of protein and organelle in living cells

This paper introduces BOLT, a tool for inducible trapping, controlled release, and visualization of proteins in living cells, demonstrating its use in tracking protein and organelle dynamics.

LRRC57/RABIN is a presynaptic inhibitor of Rab GTPases in glutamatergic neurons

The paper identifies LRRC57/RABIN as a presynaptic inhibitor of Rab GTPases in glutamatergic neurons, showing it regulates neurotransmitter release and prevents epileptiform activity.

APOE is a presynaptic protein that accumulates with age and modulates neurotransmitter release

This study identifies APOE as a presynaptic protein enriched in aged female mice, showing it modulates neurotransmitter release and affects synaptic function.

Glutamate indicators with increased sensitivity and tailored deactivation rates

The paper develops two variants of a glutamate indicator with enhanced sensitivity and tailored deactivation rates for studying synaptic transmission in vivo.

Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons

The paper shows that synaptic vesicle proteins selectively enter axons and are delivered to presynaptic membranes before being incorporated into vesicles, challenging the selective retention model.

Mitochondrial complementation occurs in rat hippocampal axons and supports the synaptic vesicle cycle.

The paper investigates mitochondrial trafficking and fusion in rat hippocampal axons, showing that mitochondrial complementation supports synaptic vesicle cycle function.

Synaptotagmin 1 oligomerization via the juxtamembrane linker regulates spontaneous and evoked neurotransmitter release

This study shows that synaptotagmin-1 multimerization via the juxtamembrane linker is essential for both spontaneous and evoked neurotransmitter release.

Synaptotagmin 7 is enriched at the plasma membrane to promote vesicle docking and control synaptic plasticity

This study investigates the role of SYT7 in synaptic function by analyzing its localization and effects on vesicle docking and synaptic plasticity in mouse hippocampal neurons.