Zahia Aouabed

Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse

This study identifies widespread gene expression changes in the neurovascular unit of female depressed suicides with childhood abuse histories, highlighting key regulators like KLF2 and KLF4.

Universal method for the gentle isolation of intact microvessels from frozen tissue: a multiomic investigation into the neurovasculature

The paper introduces a method to isolate intact microvessels from frozen tissue and uses multi-omics to characterize the neurovascular unit.

Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes

Non-CG methylation and multiple epigenetic layers associate child abuse with immune and small GTPase dysregulation

The paper investigates how early-life adversity affects epigenetic layers and gene expression in the amygdala, finding associations with immune and small GTPase dysregulation.