Author

S. Ajay Castro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

H. C. Dorfmueller· 4 shared M. Reglinski· 2 shared N. Korotkova· 2 shared S. Thomson· 2 shared A. Arunrao Pohane· 1 shared A. B. Herr· 1 shared A. E. Yarawsky· 1 shared A. Ruda· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersMicrobiology

H. C. Dorfmueller

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A platform for the recombinant production of Group A Streptococcus glycoconjugate vaccines

S. Ajay Castro, I. J. Passmore, D. Ndeh, H. A. Shaw, A. Ruda, K. Burns, S. Thomson, R. Nagar, K. Alagesan, K. Lucas, S. Abouelhadid, M. Reglinski, U. Schwarz- Linek, F. Mawas, G. Widmalm, , H. C. Dorfmueller

This study develops a platform for recombinant production of Group A Streptococcus glycoconjugate vaccines using E. coli, confirming their structural integrity and immunogenicity in animal models.

bioRxiv · Mar 1, 2024Microbiology

Recombinant Group A Carbohydrate backbone embedded into Outer Membrane Vesicles is a potent vaccine candidate targeting Group A Streptococcus from Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

S. Ajay Castro, S. Thomson, A. Zorzoli, B. H. Meyer, M. Reglinski, H. C. Dorfmueller

This study demonstrates that recombinant polyrhamnose (pRha) embedded in outer membrane vesicles (OMVs) induces potent antibodies against Group A Streptococcus, effectively killing hypervirulent strains.

bioRxiv · Nov 12, 2021 · PreprintMicrobiology

Molecular basis for recognition of the Group A Carbohydrate backbone by the PlyC streptococcal bacteriophage endolysin

H. King, S. Ajay Castro, A. Arunrao Pohane, C. M. Scholte, V. A. Fischetti, N. Korotkova, D. C. Nelson, H. C. Dorfmueller

This study identifies the molecular interaction between the PlyCB CBD of the PlyC endolysin and the pRha backbone of Group A Streptococcus and Streptococcus mutans cell wall polysaccharides.

bioRxiv · Mar 19, 2021Biochemistry

Modification of cell wall polysaccharide spatially controls cell division in Streptococcus mutans

S. Zamakhaeva, C. T. Chaton, J. S. Rush, S. Ajay Castro, A. E. Yarawsky, A. B. Herr, N. M. van Sorge, H. C. Dorfmueller, G. I. Frolenkov, K. V. Korotkov, N. Korotkova

This study shows that GroP-deficient immature SCCs spatially coordinate AtlA and MapZ localization in S. mutans, ensuring proper cell division and morphology.

bioRxiv · Jun 26, 2020Microbiology