bioRxivCell BiologyPreprint
Long non-coding RNA RGMB-AS1 as a novel modulator of Bone Morphogenetic Protein Receptor 2 signaling in pulmonary arterial hypertension
M. K. Ali, Y. Liu, J. C. Wu, V. d. J. Perez, C. J. Rhodes, A. Cao, M. R. Wilkins, M. R. Nicolls, E. F. Spiekerkoetter
Abstract
This study shows that the long non-coding RNA RGMB-AS1 is upregulated in the blood and pulmonary vascular cells of PAH patient and that it regulates BMPR2 signaling. Inhibiting RGMB-AS1 increases BMPR2 signaling and improves pulmonary vascular cell function.
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