M. R. Nicolls

This study defines the microbial biogeography of healthy Fischer 344 rats across their lifespan and identifies age-dependent changes in lactic acid bacteria in the lungs.

The paper shows that reducing ELK3 expression enhances BMPR2 signaling and improves pulmonary vascular cell function in pulmonary arterial hypertension.

The paper maps immune cell subsets in PAH lungs using MIBI-TOF, identifying mo-DCs and their role in vascular remodeling and linking immune dysregulation to disease severity in HPAH.

This study identifies PTPN1 as a regulator of BMPR2 signaling in PAH, showing its downregulation in PAH patients and link to endothelial dysfunction.

This study identifies RGMB-AS1 as an upregulated lncRNA in PAH that modulates BMPR2 signaling and improves vascular cell function when inhibited.

The paper shows that endogenous retroviruses contribute to neutrophil dysfunction and exosome-mediated pulmonary arterial hypertension.

This study shows NF45 and NF90 dynamically associate with IEG promoters, regulating their inducible expression through chromatin interactions.

This study examines changes in the B-cell antibody repertoire in SSc-PAH patients before and after B-cell depletion, revealing anomalies in B-cell development and homeostasis that reverse temporarily.