Nature CommunicationsNeurosciencePeer-reviewed journal article
Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types
Lauren C. FagetiD, Lucie OrioliD, Wen-Chun LeeiD, Vivien ZelliD, Cody Sargent, Andrew J. FloresiD, Nick G. HolloniD, Dhakshin RamanathaniD, Thomas S. HnaskoiD
Abstract
The ventral pallidum (VP) contains GABA and glutamate (Glut) neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the cell-type-specific mechanisms by which VP projections to VTA drive behavior. Here, we found that both VP GABA and Glut neurons were activated during approach to reward or delivery of an aversive stimulus. Stimulation of VP GABA neurons inhibited VTA GABA, but activated dopamine (DA) and glutamate neurons. Remarkably, this cell-type-specific recruitment was behavior-contingent such that VTA recruitment was inhibited when evoked by the subjects own action. Conversely, VP Glut neurons activated VTA GABA, as well as DA and Glut neurons, despite driving aversion. However, VP Glut neurons evoked DA in reward-associated ventromedial nucleus accumbens (NAc), but reduced DA in aversion-associated dorsomedial NAc. These findings show how heterogeneous VP cell types can engage VTA cell types to shape approach and avoidance behaviors. HIGHLIGHTSO_LIVP GABA and Glut neurons are activated by approach to reward and aversive stimuli C_LIO_LIVP GABA and Glut neurons oppositely affect VTA GABA, both activate VTA DA and Glut C_LIO_LIVP Glut neurons activate DA release in ventral NAc but inhibit DA from dorsal NAc C_LIO_LIVTA DA responses to VP GABA activity are inhibited by the subjects own action C_LI
- organism: mouse
- assay: electronic health records
- research focus: cell type annotation
- research focus: cell-cell communication
- research focus: differential expression
- research focus: drug response / drug discovery
- approach: experimental assay
- Citations
- 34
- FWCI
- 5.95
- Field percentile
- top 3%
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