Nature CommunicationsNeurosciencePeer-reviewed journal article
Molecularly distinct astrocyte subpopulations spatially pattern the adult mouse brain
Mykhailo Y. BatiukiD, Araks MartirosyaniD, Jérôme WahisiD, Filip de Vin, Catherine MarneffeiD, Carola Kusserow, Jordan KoeppeniD, João Filipe VianaiD, João Filipe OliveiraiD, Thierry VoetiD, Chris Paul PontingiD, T. Grant BelgardiD, Matthew G. HoltiD
Abstract
Astrocytes are a numerous cell type of the central nervous system. They perform many important functions in synapse formation and maintenance, control of local homeostasis and modulation of synaptic transmission. However, the degree to which specialist astrocyte subtypes fulfil these specific tasks is currently unclear. Here we use single cell transcriptomics to demonstrate that astrocytes, even those lying within the same region of adult mouse brain, show distinct molecular and spatial profiles, with profound implications for local CNS functions, including axon guidance, synaptogenesis and synaptic transmission.
- organism: mouse
- assay: scRNA-seq
- research focus: clustering
- research focus: differential expression
- research focus: cell type annotation
- approach: statistical model
- Citations
- 806
- FWCI
- 34.78
- Field percentile
- top 1%
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