João Filipe Oliveira

Hippocampal astrocytes contribute to encoding context-specific aversive stimuli to regulate fear-related behavior

This study shows that hippocampal astrocytes encode context-specific aversive stimuli to regulate fear-related behavior through Ca2+ activity preceding freezing responses.

The loss of Tau in the adult brain triggers neuroplastic, epigenetic and behavioral deficits

This study shows that loss of normal Tau function in the adult brain causes neuronal atrophy, epigenetic changes, and cognitive/mood deficits, which can be reversed by Tau re-expression or epigenetic correction.

Astrocytic mGluR5 signaling tunes emotional and cognitive processing in the adult brain

This study investigates the role of astrocytic mGluR5 signaling in adult mice, showing its impact on emotional and cognitive behaviors through hippocampal function.

Neuronal expression of S100B triggered by oligomeric Aβ peptide protects against cytoskeletal damage and synaptic loss

This study shows that neuronal S100B expression is triggered by Aβ oligomers and protects against cytoskeletal damage and synaptic loss in Alzheimer's disease.

Astrocytic Foxo1 regulates hippocampal spinogenesis and synaptic plasticity to enhance fear memory

This study identifies Foxo1 as a key regulator of astrocytic calcium signaling in the hippocampus, influencing spinogenesis, synaptic plasticity, and fear memory.

Constitutive AP2gamma deficiency reduces postnatal hippocampal neurogenesis and induces behavioral deficits in juvenile mice that persist during adulthood

This study shows that AP2gamma deficiency in mice reduces hippocampal neurogenesis and causes lasting behavioral deficits from juvenile to adult stages.

Astrocyte-derived TNF and glutamate critically modulate microglia reactivity by methamphetamine

This study shows that Meth exposure causes microglia reactivity through astrocyte-derived TNF and glutamate, affecting behavior in adult mice.

Molecularly distinct astrocyte subpopulations spatially pattern the adult mouse brain

The paper identifies molecularly distinct astrocyte subpopulations in the adult mouse brain and shows their spatial distribution has functional implications.