clinical cohort / trial

This study compares phantomless and inline phantom-based densitometric calibration of vertebral properties from CT scans, finding a strong correlation between the two methods using air and aorta as calibration regions.

This study examines how mutualism affects legume niches globally, finding that mutualist species occupy broader niches than non-mutualists, with effects varying by mutualism type and latitude.

This study characterizes a leptospirosis outbreak in dogs in Los Angeles County, finding that all isolates were Leptospira interrogans serovar Canicola, with urine PCR as the most sensitive test and ICFs as a potential source.

This study shows HS3ST1 deficiency worsens lung injury and increases mortality after trauma and hemorrhagic shock, particularly with fresh frozen plasma resuscitation.

This study identifies NCOR2 as an epigenetic repressor of MHC class I expression in breast cancer, promoting metastasis by inhibiting immune surveillance.

This study examines how type 2 diabetes affects prostate cancer progression, finding associations with advanced tumor stage, lymph node involvement, and altered tumor cell dissemination and vascular characteristics.

The paper identifies pre-existing anti-prophage antibodies and bacterial heteroresistance as factors contributing to phage therapy failure in a patient with chronic infection.

The paper examines how early life environments affect adult cardiometabolic health in the Orang Asli, finding support for developmental constraints over predictive adaptive responses.

This study identifies three distinct hemodynamic phenotypes in high-altitude dwellers and links them to subclinical organ damage.

This paper develops a hybrid PINN-DE framework for parameter estimation in tumor-immune dynamics of bladder cancer, showing improved accuracy and efficiency compared to individual methods.

The paper identifies anti-CE1 antibodies that reduce HCC incidence and mortality by mediating NK cell ADCC against ASPH-expressing tumor cells through epitope mimicry.

WildAlert detects wildlife health anomalies using AI and real-time clinical data, identifying events like HPAI and algal blooms before confirmed outbreaks.

This paper systematically reviews NMN and NR trials, assesses transitivity, and performs indirect comparisons, finding structural limitations prevent reliable comparison of their metabolic effects.

This paper evaluates CF10, a novel polymeric fluoropyrimidine, showing superior antitumor activity and survival benefit in patient-derived colorectal cancer models compared to 5-FU.

This study identifies metabolic factors associated with disease activity and complications in Crohn's disease using regression analysis and predictive models.

This study shows that the CRKp lineage CG307 is increasing in UTIs in the Southern US and has traits promoting urinary tract tropism.

The paper investigates whether drugs causing biliary toxicity, like Augmentin, are linked to cholangiocarcinoma development, finding no statistically significant association.

This study shows that DPP-4 inhibition improves CD8+ T cell metabolism and anti-tumor activity in preclinical and clinical settings.

This paper applies a financial engineering model to TB survival analysis, identifying BMI thresholds and HIV's impact on mortality risk using a large Cameroonian cohort.

This study compares nonlinear mixed-effects and Bayesian hierarchical models for pharmacokinetics of ceftolozane-tazobactam in critically ill patients, showing that Bayesian methods improve parameter consistency with literature when prior information is included.

This paper develops a patient-specific mathematical model of LVAD-supported ventricles using clinical ramp-test data and validates it through hybrid modeling to assess intrinsic LV function.

This study evaluates the effects of SGLT2 inhibitors in preclinical PAH models, finding significant improvements in pulmonary hemodynamics and right ventricular function.

This study shows stress hormones induce neutrophil extracellular trap formation, linking inflammation to behavioral changes in mice and humans.

This study compares vibriosis incidence and causative species between equatorial Singapore and temperate United States, finding higher incidence in Singapore with stable rates, while US rates are rising, suggesting ecological impacts of warming oceans.

This study shows that antiretroviral treatment (ART) does not prevent extrapulmonary tuberculosis in SIV/Mtb co-infected macaques, despite suppressing SIV replication.

This study reviews and analyzes the effects of simulated microgravity on hematological and anemia-related biomarkers in humans, finding hemoconcentration, erythropoietin suppression, and altered iron metabolism.

This paper identifies FOXJ1 as a mediator of taxane resistance in prostate cancer by regulating microtubule dynamics, with clinical implications for patient stratification.

This study models oseltamivir's effects on viral shedding and symptom outcomes in experimental influenza infections using clinical trial data, finding no significant antiviral efficacy or dose-dependent effects.

This paper develops a machine learning model to predict post-stroke aphasia speech performance using multimodal data, achieving high accuracy with explainable features.