metabolism & bioenergetics

This study investigates mitochondrial remodeling and metabolic changes in zebrafish Muller glia during retinal regeneration, showing compartment-specific mitochondrial changes and the role of PDK/PDH regulation.

This study shows that Rab7 activation improves lysosomal dynamics and mitophagic flux in iron overload, enhancing mitochondrial function and cell survival.

This study shows that Clostridium tyrobutyricum can effectively produce butyric acid from xylose-rich substrates despite carbon catabolite repression.

This study shows that PPI-associated microbiome changes cause systemic metabolic and transcriptional responses, affecting metabolism and inflammation in multiple tissues.

The paper introduces scTPPM, a single-cell multi-omics approach that co-profiles transcriptomes, proteomes, eight PTMs, and metabolomes, revealing dynamic crosstalk during mouse oocyte meiosis.

This study uses polygenic scores to identify pleiotropic effects of psychiatric dimensions across medical and laboratory phenotypes, revealing biological links between mental health and physical conditions.

This study identifies ASP as a modulator of host cell homeostasis through proteomics and functional validation, revealing its role in DNA repair and mitochondrial function.

This study identifies 28S rsRNA-CTC_L20 as a regulator of PASMC proliferation in pulmonary hypertension by modulating BHB production and PKM2 β-hydroxybutyrylation.

This study investigates brain-body interactions during food anticipation using multimodal physiological recordings, finding distinct changes in gastric and cortical responses linked to appetite and craving.

LuCEMe is a luciferase-based method to assess cellular metabolism in various systems, revealing metabolic differences in cancer and immune cell interactions.

The paper characterizes microbial communities and metabolic potential in northern palsa and peat ecosystems, finding distinct microbial profiles and highlighting hydrogen and carbon monoxide metabolism as key energy sources.

This study shows that older adults exhibit enhanced implicit motor adaptation only with consistent errors, not variable ones, suggesting error consistency is key for age-related adaptation.

This study investigates changes in carotid body mitochondrial function in heart failure, finding decreased oxygen affinity and increased oxidative stress.

This study shows ATF3 helps macrophages manage cholesterol during metabolic stress by balancing inflammation and sterol-responsive gene expression.

This paper uniformly re-analyzes public omics data from exercise studies in humans and rodents, providing standardized effect sizes and meta-analyses across multiple tissues and molecular layers.

The paper uses genome-scale modelling and stable isotope tracing to study metabolic changes in human cardiac hypertrophy models.

This study evaluates a M4-selective PAM in nonhuman primates, showing broad cognitive and motivational improvements without adverse side effects.

The paper shows neurons entrain an intrinsic arteriole rhythm, shaping blood distribution and vascular responses through frequency-dependent mechanisms.

This study identifies an internal chemosensory system in Drosophila melanogaster's abdomen using Gustatory Receptors, revealing new roles in interoception beyond traditional feeding behaviors.

This study examines proteomic changes in Geodermatophilus obscurus G20 under UV stress, showing distinct responses in acute and recovery phases.

This study examines the effects of isocaloric high-fat diet restriction with TAK-242 on metabolic and gut microbial responses in mice, finding limited normalization of adiposity and microbial community.

The paper identifies oleate depletion as a metabolic signal sensed by C. elegans to activate innate immunity against bacterial infection.

This study examines sex differences in muscle volume, strength, and motor unit properties during bed rest and retraining in young males and females, finding no sex differences in strength loss but greater MU firing rate reduction in females.

This study identifies Roseburia hominis-derived 10-hydroxystearic acid as a metabolite that improves metabolic health by restoring hepatic fatty acid metabolism in mice.