Gut microbiota and health

This study tracks how the gut microbiome and host fitness of Pacific pocket mice change across generations in captivity, finding that microbiomes stabilize after two to three generations and correlate with reproductive success.

This study integrates host and sample metadata with microbiome abundance profiles to improve disease prediction models using machine learning.

This study identifies consistent taxonomic and functional gut microbiota changes associated with Trichuris trichiura infection across three countries, revealing shared ecological responses and metabolic impacts.

This study examines how stool timing, sleep, and feeding affect the gut microbiome composition in infants, finding associations between longer intervals since last defecation and increased microbial diversity.

This study shows that Faecalibacterium prausnitzii induces IL-10 production and metabolic changes in human monocytes, with anti-inflammatory effects and mitochondrial dependence.

MaAsLin 3 fits hurdle models separating microbial prevalence (augmented logistic) and abundance (median-adjusted log-linear) associations, improving precision over existing differential abundance tools and showing 77% of IBD associations are prevalence-driven.

Vitamin A deficiency in mice causes epithelial remodeling, ciliary dysfunction, loss of mucociliary clearance, and increased microbial abundance in the lungs.

This study models collection-induced bias in microbiome multi-omics using a fermentation system, showing temperature strongly affects microbial and metabolic profiles.

This paper presents a comprehensive analysis of the faecal microbiomes of 23 marsupial species, revealing novel microbial genomes and highlighting the influence of host phylogeny on microbiome composition.

This study assesses public and healthcare professionals' knowledge of gut microbiota and evaluates their understanding of its health links to improve communication strategies.

This paper presents a rapid diagnostic test to measure fecal butyrate and deoxycholic acid concentrations as markers of microbiome function, enabling quick identification of patients with microbiome deficiencies.

This study identifies urea carbon salvage as a mechanism enabling hibernating squirrels to reuse urea and mucins for energy during fasting.

This study examines the association between gut microbiome diversity and 24-hour blood pressure variability, identifying sex-specific bacterial species linked to systolic and diastolic blood pressure fluctuations.

This study shows dietary tryptophan improves AhR activation and reduces colitis by enhancing microbial tryptophan metabolism in preclinical models.

The paper identifies a novel gene cluster in Bifidobacterium pseudolongum that enables resistant starch utilization, linking CAZyme profiles to niche adaptation in infant and adult microbiomes.

The paper develops a Bayesian framework to infer metabolite-bacteria interactions in microbial communities using dynamic network models and time-series data.

This study shows that Prevotella intestinalis induces arthritis in resistant mice by activating intestinal immune cells and promoting Th17 differentiation through IL-6.

TAGINE optimizes microbiome feature sets using taxonomy-based splitting, reducing features while maintaining accuracy and speed.

This study examines how increasing pea protein intake affects gut microbiota and inflammatory biomarkers in healthy adults, finding changes in specific bacterial abundances and fecal markers.

The paper assesses colonization resistance against C. difficile in human gut microbiota by testing donor stool in mice, finding a graded resistance spectrum rather than a binary trait.

This study identifies distinct duodenal microbiota and immune profiles in functional dyspepsia patients compared to controls, suggesting disrupted host-microbiome homeostasis.

This study develops a genome-scale metabolic model of Flavonifractor plautii to explore its probiotic potential and ecological roles in the gut microbiota.

The paper analyzes the prevalence of propionate and butyrate producing pathways in the human gut microbiota across different age groups and birth methods, finding significant variations linked to host physiology.

R package NeighborFinder infers a focal species' co-abundance neighbors via repeated cross-validated ℓ1 regression, reaching F1 ≥ 0.95 on simulated cohorts of 250 to 1000 samples.

This study shows that dietary protein source affects colitis severity by altering gut bacteria and bile acid profiles, with beef protein causing more severe inflammation than pea protein.

This study examines how the home environment affects infant gut microbiota development in 893 children, finding minimal overall associations but significant effects of air quality and proximity to agriculture.

This paper evaluates a high-throughput single-cell dispensing platform for isolating Bifidobacterium strains from fecal samples, demonstrating its effectiveness in recovering diverse, novel bacterial isolates.

This study shows that a fiber-rich diet alters alveolar macrophage metabolism and lung injury responses via gut microbiome-derived propionate.

This study identifies Sutterella wadsworthensis as a low-abundant intestinal commensal that suppresses anti-leukemia immune responses in chronic myeloid leukemia.

This study analyzes marsupial gut microbiomes to identify genetic factors contributing to their low methane emissions compared to ruminants.