A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis
Yuqing Wang, Duolong Zhu, Laura Ortiz-Velez, Jacob L. Perry, Michael W. Pennington, Joseph M. Hyser, Robert A. Britton, Christine Beeton
This paper develops a bioengineered probiotic to deliver a Kv1.3 channel blocker peptide for treating rheumatoid arthritis, showing efficacy in reducing inflammation and joint damage in rat models.
Proceedings of the National Academy of Sciences · Jan 3, 2023Peer-reviewedSynthetic Biology