Robert A. Britton

The paper isolates and characterizes small intestinal Lactobacillaceae strains, showing their ability to modulate host immune and hormonal responses in preclinical models.

The paper introduces a modular bioelectronic sensor system using synthetic microbial co-cultures to detect various analytes in different environments.

The paper shows that infant gut microbiomes influence metabolic states that affect brain function, with interventions restoring normal behavior in mice.

This study shows that bacteriophages can reduce uropathogenic E. coli (UPEC) colonization in vitro and in a mouse model, suggesting phage therapy as a potential UTI prevention strategy.

The paper characterizes a non-toxigenic C. difficile strain, L-NTCD03, showing antimicrobial resistance and non-toxicity, suggesting its potential as a live biotherapeutic.

The paper optimizes a microbial biosensor to detect and respond to the clinically relevant intestinal inflammation biomarker calprotectin.

This study shows that L. reuteri strains promote the expression and secretion of gut hormones from enterocytes, expanding understanding of their physiological effects.

This study profiles carbon metabolism in C. difficile clinical isolates, revealing lineage-specific metabolic capabilities and divergence in two emerging ribotypes.

The paper develops a model to estimate infant gut microbiome age using metagenomic data, finding conserved microbial succession patterns across diverse human populations.

This paper reports the cultivation of human noroviruses in human intestinal enteroids, revealing segment- and strain-specific differences in viral replication and highlighting the utility of genetically modified enteroids for broader strain cultivation.

The paper identifies 25 rRNA modification sites in B. subtilis and links them to RbgA-dependent large subunit assembly.

This paper develops a bioengineered probiotic to deliver a Kv1.3 channel blocker peptide for treating rheumatoid arthritis, showing efficacy in reducing inflammation and joint damage in rat models.

This study identifies major sources of transcriptomic variation in human intestinal organoids, showing that culture methods like substrate and format have large effects compared to experimental manipulations.

The paper describes a crowdsourcing initiative, CACAO, where undergraduates contribute gene function annotations to the Gene Ontology, enhancing coverage and enabling community-driven curation.

This study investigates Era's role in 30S ribosomal subunit assembly using mass spectrometry, cryo-EM, and in-cell footprinting, showing that most rRNA domains can fold without Era and that Era binding affects the decoding center.