Pregnancy and preeclampsia studies

Engineered trophoblast organoids recapitulate molecular and functional features of preeclampsia

This paper develops a genetically engineered trophoblast organoid model of preeclampsia that recapitulates molecular and functional features of the disease.

Persistent cerebrovascular injury after preeclampsia in the STOX1A mouse model: implications for prokineticin signaling

This study examines persistent cerebrovascular injury after preeclampsia in a mouse model and shows that prokineticin receptor antagonism reduces some cerebral abnormalities.

Topological dependent modifications of gene expression in the preeclamptic placenta under aspirin treatment.

This study identifies aspirin's molecular effects on preeclamptic placenta by analyzing gene expression in different placental regions, showing downregulation of inflammatory and metabolic pathways.

Shared Genetics of Hypertension and Preeclampsia Converges on Immune Regulation

The paper identifies shared genetic variants between hypertension and preeclampsia that regulate immune-related genes, linking gene expression to blood pressure traits and clinical phenotypes.

Creatine phosphagen system regulates energy metabolism and growth of trophoblasts

This study investigates the role of the creatine phosphagen system in trophoblast development and shows that disrupting it impairs bioenergetics, proliferation, and survival.

Osteopontin Mediates Uterine Artery Dysfunction in Hypertensive Pregnancy

This study identifies osteopontin as a mediator of impaired uterine artery remodelling in hypertensive pregnancy, showing its deficiency improves vascular function and fetal growth.

Advanced Maternal Age Impairs Decidual Angiogenesis and Spiral Artery Remodelling

This study shows that advanced maternal age impairs decidual angiogenesis and spiral artery remodeling in mice, contributing to pregnancy complications and cardiovascular risk.

PARP1/2-linked ADP-ribosylation impairs trophoblast mitochondrial respiration in a TNF-α model of inflammation-mediated preeclampsia.

This study shows PARP1/2-linked ADP-ribosylation impairs trophoblast mitochondrial respiration in inflammation-mediated preeclampsia, with olaparib improving respiration.

Genetic Variants Associated with Placental Abnormalities in Stillbirths

The paper identifies genetic variants associated with placental abnormalities in stillbirths by analyzing exome sequencing data from placental and fetal samples.