Aortic Disease and Treatment Approaches

Unraveling the Molecular Complexity of Bicuspid Aortopathy: Lessons from Comparative Proteomics

The paper identifies molecular pathways and biomarkers associated with bicuspid aortopathy using proteomics in a hamster model and patient studies.

Plasma Cell-Free DNA in Acute and Chronic Aortic Syndromes.

The paper shows plasma short-fragment cfDNA concentration is higher in acute and chronic aortic disease compared to controls and is higher in acute cases, suggesting it could be a diagnostic biomarker.

Modeling Thoracic Aortic Dissection Using Patient-Specific iPSCs Reveals VSMC Dysfunction and Extracellular Matrix Dysregulation

This study uses patient-specific iPSCs to model thoracic aortic dissection, revealing VSMC dysfunction and extracellular matrix dysregulation linked to COL4A2 mutations and TGF-β signaling.

A Patient-Specific Morphoelastic Growth Model of Aortic Dissection Evolution

This paper develops a patient-specific morphoelastic growth model to predict aortic dissection progression using CT scans and finite element analysis.

Triphasic Thrombosis Model: A Computational Study of Type B Aortic Dissection

The paper develops a computational model of thrombosis using porous media theory to simulate thrombus growth in type B aortic dissection and compares results with MRI data.

Barriers to cascade screening in people at risk of Thoracic Aortic Disease: a mixed methods evaluation from the DECIDE-TAD initiative

This study identifies barriers to cascade screening for thoracic aortic disease using mixed methods, finding low uptake due to awareness, health literacy, and cost concerns.

Differentiation between Descending Thoracic Aortic Diseases using Machine Learning and Plasma Proteomic Signatures

This paper uses machine learning to differentiate between descending thoracic aortic diseases using plasma proteomic data, identifying key proteins and pathways associated with each condition.

Elevated ENO2 Disrupts VSMCs Homeostasis Facilitating the Development of Aortic Dissection

This study shows that elevated ENO2 disrupts autophagy in vascular smooth muscle cells, contributing to aortic dissection development.

Identification of Aorta-Specific DNA Methylation Patterns in Cell-Free DNA from Patients with Bicuspid Aortic Valve-Associated Aortopathy and Correlation with Aortic Wall Cell Death

The paper identifies aorta-specific DNA methylation patterns in cell-free DNA from BAV-associated aortopathy patients and correlates them with aortic wall cell death.

A study of the neuronal injury biomarkers pNF-H and UCHL1 in serum, CSF and urine in a cohort of thoracic endovascular aortic repair (TEVAR) patients.

This study measures pNF-H and UCHL1 levels in serum, CSF, and urine of TEVAR patients, finding elevated levels correlate with poor outcomes like death, renal failure, and spinal cord ischemia.

Verify Hub Genes of expression profile in aortic dissection

The paper identifies hub genes and molecular pathways associated with thoracic aortic dissection using microarray analysis and bioinformatics.