Aortic Disease and Treatment Approaches

Genetic support for an adverse effect of calcium channel blockers on the human thoracic aorta

This study uses Mendelian randomization to assess the causal role of CACNA1C, a target of calcium channel blockers, on thoracic aortic aneurysm and dissection, finding lower risk with higher aortic expression.

Associations of age, sex, and bicuspid aortic valve with biaxial mechanical properties and circumferential residual stress in ascending thoracic aortic aneurysm

This study examines how age, sex, and bicuspid aortic valve influence mechanical properties and residual stress in ascending thoracic aortic aneurysms.

Cellular-Resolution Spatial Transcriptomics Reveals Laminar VSMC Phenotypic Remodeling and a Hypoxic Medial Core in Human Thoracic Aortic Dissection

The paper uses spatial transcriptomics to identify hypoxia-adapted VSMC remodeling in human aortic dissection, linking it to interlamellar separation.

ACAN regulates VSMC mitochondrial homeostasis through the YAP1/TAZ pathway and contributes to the onset and progression of aortic dissection

This study shows ACAN promotes aortic dissection by disrupting mitochondrial homeostasis in VSMCs via the YAP1/TAZ pathway, and its reduction improves disease outcomes.

Circulating APOH promotes aortic dissection by activating the vascular smooth muscle cell NR5A1-PPARγ pathway.

This study identifies APOH as a promoter of aortic dissection by activating the NR5A1-PPARγ pathway in vascular smooth muscle cells, leading to phenotypic switching and inflammation.

Increased Interstitial Flow and Elastic Lamina Degradation Precede Aortic Dissection

This study shows that increased interstitial flow and elastic lamina degradation occur before aortic dissection in a mouse model.

Myeloid Suclg2 deficiency attenuates aortic dissection by reshaping succinate-associated macrophage remodelling

This study shows that myeloid Suclg2 deficiency reduces aortic dissection by altering macrophage metabolism and systemic metabolic profiles.

Elastogenesis by adventitial progenitors acquiring a smooth muscle cell phenotype following aortic dissection

This study identifies that adventitial progenitor cells differentiate into elastogenic SMC-like cells, contributing to false lumen remodeling through de novo elastic fiber formation following aortic dissection.

GYS2 Promotes the Progression of Aortic Dissection and Aortic Aneurysm via C5a/NF-κB-Mediated Pro-Inflammatory Macrophage Polarization

This study shows that GYS2 promotes aortic dissection and aneurysm by driving pro-inflammatory macrophage polarization through the C5a/NF-κB pathway.

Hydraulic fracturing-induced delamination and extravasation extends medial damage beyond the false lumen in aortic dissection

The paper investigates how hydraulic fracturing in aortic dissection causes medial damage beyond the false lumen, leading to structural weakening of the aortic wall.

Increased medial collagen enhances aortic resilience against mural delamination from hydraulic fracturing

This study investigates how increased medial collagen affects aortic resilience against mural delamination by analyzing pressure responses in human aortic specimens under different conditions.

Controlled intramural fluid injection to quantify propensity to thoracic aortic dissection

This study quantifies how axial stretch, injection rate, and needle gauge influence intramural delamination in porcine aortas, revealing a hydraulic fracture mechanism in layered tissue.

A correlational study of ABCA3 and SCN4B as exercise-related biomarkers of patients with Stanford type A aortic dissection

This study identifies ABCA3 and SCN4B as exercise-related biomarkers for Stanford type A aortic dissection and suggests potential therapeutic drugs.

Epigenetic Programming of Macrophage Phenotypes by STING-IRF3 Drives Inflammation in Ascending Thoracic Aortic Dissection

This study identifies STING-IRF3-mediated epigenetic programming of macrophages as a driver of inflammation in aortic dissection, showing its role in pro-inflammatory bias and therapeutic potential.

Mechanisms Driving Thoracic Aortic Aneurysm Stability

This paper develops a computational biomechanical model to simulate thoracic aortic aneurysm progression and predict outcomes like stabilization or rupture.

NPAS2 attenuates VSMC phenotypic switching in ascending thoracic aortic aneurysm via LPCAT3/PC-PUFA2S-mediated ferroptosis

This study identifies NPAS2 as a regulator of VSMC phenotypic switching in ATAA by modulating LPCAT3/PC-PUFA2S-mediated ferroptosis.

Pathological Angiogenesis Precedes the Onset of Aortic Dissection

This study identifies pathological angiogenesis as a key driver of non-heritable aortic dissection, revealing its role in disease onset and potential therapeutic targets.

Integrative Omics Identifies Candidate Plasma Biomarkers and Cellular Targets Associated with Thoracic Aortic Aneurysm

This study identifies 25 cellular subsets in thoracic aortic aneurysm tissue and links FGF-23 as a plasma biomarker associated with aortic diameter and disease.

CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection

This paper identifies CTHRC1 as a therapeutic target and serum biomarker for aortic dissection, showing it regulates VSMC phenotype and aortic integrity via the ERK1/2 pathway.

AT1R and Integrin β3 Synergize to Drive Aortic Dissection via Non-Canonical Wnt/β-Catenin Signaling

This study identifies integrin β3 as a key driver of aortic dissection, showing its synergy with AT1R via non-canonical Wnt/β-catenin signaling, and suggests dual-target therapy as a potential treatment.

Pharmacological inhibition of mitochondrial fission mitigates experimental thoracic aortic aneurysm

This study shows that inhibiting mitochondrial fission with mdivi-1 reduces thoracic aortic aneurysm (TAA) progression in mice by limiting vascular remodeling and inflammation.

Molecular reprogramming of adventitial pericytes by a selective MEK inhibitor halts the progression of thoracic aortic aneurysm

This study shows that inhibiting MEK signaling with PD0325901 restores pericyte function and halts thoracic aortic aneurysm progression in mice.

Plasma Cell-Free DNA in Acute and Chronic Aortic Syndromes.

The paper shows plasma short-fragment cfDNA concentration is higher in acute and chronic aortic disease compared to controls and is higher in acute cases, suggesting it could be a diagnostic biomarker.

Triphasic Thrombosis Model: A Computational Study of Type B Aortic Dissection

The paper develops a computational model of thrombosis using porous media theory to simulate thrombus growth in type B aortic dissection and compares results with MRI data.

Barriers to cascade screening in people at risk of Thoracic Aortic Disease: a mixed methods evaluation from the DECIDE-TAD initiative

This study identifies barriers to cascade screening for thoracic aortic disease using mixed methods, finding low uptake due to awareness, health literacy, and cost concerns.

Differentiation between Descending Thoracic Aortic Diseases using Machine Learning and Plasma Proteomic Signatures

This paper uses machine learning to differentiate between descending thoracic aortic diseases using plasma proteomic data, identifying key proteins and pathways associated with each condition.

Elevated ENO2 Disrupts VSMCs Homeostasis Facilitating the Development of Aortic Dissection

This study shows that elevated ENO2 disrupts autophagy in vascular smooth muscle cells, contributing to aortic dissection development.

A study of the neuronal injury biomarkers pNF-H and UCHL1 in serum, CSF and urine in a cohort of thoracic endovascular aortic repair (TEVAR) patients.

This study measures pNF-H and UCHL1 levels in serum, CSF, and urine of TEVAR patients, finding elevated levels correlate with poor outcomes like death, renal failure, and spinal cord ischemia.

Verify Hub Genes of expression profile in aortic dissection

The paper identifies hub genes and molecular pathways associated with thoracic aortic dissection using microarray analysis and bioinformatics.