Topic · Aging · Biochemistry, Genetics and Molecular Biology

Genetics, Aging, and Longevity in Model Organisms

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

2 papers

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

Andrea Di Francesco, Andrew G. Deighan, Lev Litichevskiy, Zhenghao Chen, Alison Luciano, Laura L. Robinson, Gaven Garland, Hannah Donato, Matthew J. Vincent, Will Schott, Kevin M. Wright, Anil Raj, G.V. Prateek, Martin N. Mullis, Warren G. Hill, , Gary A. Churchill

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

Nature · Oct 9, 2024Peer-reviewedGenetics✦ In-depth digest

Undulating changes in human plasma proteome across lifespan are linked to disease

Benoit Lehallier, David Gate, Nicholas Schaum, Tibor Nánási, Song Eun Lee, Hanadie Yousef, Patricia Morán Losada, Daniela Berdnik, Andreas Keller, Joe Verghese, Sanish Sathyan, Claudio Franceschi, Sofiya Milman, Nir Barzilai, Tony Wyss‐Coray

Profiling 2,925 plasma proteins in 4,331 people aged 18-95 reveals non-linear aging: protein waves crest at 34, 60 and 78 years, later waves overlapping disease proteomes.

Nature Medicine · Dec 1, 2019Peer-reviewedSystems Biology✦ In-depth digest