Ion Transport and Channel Regulation

RNA-Seq and Protein Mass Spectrometry in Microdissected Kidney Tubules Reveal Signaling Processes that Initiate Lithium-Induced Diabetes Insipidus

The paper uses RNA-Seq and protein mass spectrometry on microdissected kidney tubules to identify signaling pathways involved in lithium-induced diabetes insipidus, showing NF-κB activation and reduced aquaporin-2 expression.

Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis

The paper uses biophysical models to show that cation-chloride cotransporters, not impermeant anions, primarily modulate chloride driving force in neurons.

Highly tamoxifen-inducible principal-cell-specific Cre mice with complete fidelity in cell specificity and no leakiness

This paper describes a tamoxifen-inducible Cre mouse model with complete cell specificity and no leakiness for studying principal cells in the kidney.

Hypoosmolar dose-dependent swelling occurs in both pyramidal neurons and astrocytes in acute hippocampal slices

This study shows that both pyramidal neurons and astrocytes swell in hypoosmolar conditions, challenging the notion of neuronal osmoresistance and revealing an AQP4-independent mechanism for osmotic swelling.