Ion Transport and Channel Regulation

Cell-Driven Fluid Dynamics: A Physical Model of Active Systemic Circulation

The paper develops a mathematical model that integrates pressure and osmolarity gradients in systemic circulation, showing how cell properties influence transport and vice versa.

Role of Kir4.1/Kir5.1 in mediating Angiotensin-II (Ang-II)-induced stimulation of thiazide-sensitive Na-Cl cotransporter.

This study investigates how Ang-II affects NCC through Kir4.1/Kir5.1 in the DCT, finding that short-term effects depend on Kir4.1/Kir5.1, while long-term effects are independent.

SWEET family transporters act as water conducting carrier proteins in plants

This study shows SWEET family transporters in plants act as water-conducting carrier proteins through multiple mechanisms, validated by simulations and experiments.

Vasopressin-Dependent β-Catenin Phosphorylation at Ser552 and Branching Structure of Mouse Collecting Duct System

This study shows that mutating Ser552 in β-catenin in mice alters collecting duct branching without affecting differentiation, suggesting vasopressin-mediated phosphorylation at Ser552 influences CD development.

Structural basis of autoantibody binding in Neuromyelitis Optica

This study determines the structural basis of autoantibody binding to aquaporin-4 in NMO, revealing epitope diversity on tetrameric and higher-order assemblies.

Rapid microfluidic perfusion system enables controlling dynamics of intracellular pH regulated by Na+/H+ exchanger NHE1

This study develops a microfluidic system to control intracellular pH dynamics and validates a mathematical tool to translate fluorescence signals to pH values, revealing overshooting and undershooting pH responses.

AER-270 and TGN-020 are not aquaporin-4 water channel blockers

This study shows that AER-270 and TGN-020 do not inhibit AQP4, contradicting their classification as AQP4 blockers and suggesting alternative mechanisms.

Protein modelling and thermodynamics reveal that plant cation-chloride cotransporters mediate potassium-chloride symport

This study uses structural modeling and experimental data to show plant cation-chloride cotransporters function as K+-Cl- symporters, not Na+-K+-2Cl- transporters.

SLC4A1 MUTATIONS THAT CAUSE DISTAL RENAL TUBULAR ACIDOSIS ALTER CYTOPLASMIC PH AND CELLULAR AUTOPHAGY

This study investigates how SLC4A1 mutations in dRTA affect intracellular pH and autophagy in mouse kidney cells.

Aquaporin-4 expression levels and mis-localization are inversely linked to peritumoral edema in gliomas of varying aggressiveness

This study compares AQP4 and AQP4ex expression and localization in low-grade and high-grade gliomas, finding inverse relationships with peritumoral edema and tumor aggressiveness.

Osmotic Volume Flow in a Donnan System with PermeantIons

The paper derives an equation for Donnan osmosis across a Debye energy barrier and applies it to ion pumps and capillary transport.

Oligomerization and cellular localization of SLC26A11

This study investigates the oligomerization and cellular localization of SLC26A11, finding it does not heterodimerize with other SLC26 proteins and remains localized to lysosomes.

Evaluation of gliovascular functions of Aqp4 readthrough isoforms

This study evaluates the role of AQP4 readthrough isoforms in gliovascular functions using a novel mouse model and finds that AQP4x modulates BBB integrity and protein localization.

Neural activity induces strongly coupled electro-chemo-mechanical interactions and fluid flow in astrocyte networks and extracellular space - a computational study

Aquaporin regulates cell rounding through vacuole formation during endothelial-to-hematopoietic transition

The paper shows that aquaporin-1 regulates cell rounding and detachment during endothelial-to-hematopoietic transition by promoting vacuole formation in hemogenic endothelial cells.

Conditional deletion of LRRC8A in the brain protects against stroke damage independently of effect on swelling-activated glutamate release

This study shows that deleting LRRC8A in the brain reduces stroke damage without affecting glutamate release, challenging the idea that VRACs contribute to stroke via glutamate release.

NHA1 is a cation/proton antiporter essential for the water-conserving functions of the rectal complex in Tribolium castaneum

The paper identifies NHA1 as a critical cation/proton antiporter in the rectal complex of Tribolium castaneum, essential for water conservation through ion transport and developmental regulation.

Function and evolution of aquaporin IsAQP1 in the Lyme disease vector Ixodes scapularis

This study identifies and functionally characterizes IsAQP1, an aquaporin in Ixodes scapularis, showing it is a water channel with low glycerol permeability and salivary gland-specific expression.

Lateral diffusion of NKCC1 contributes to neuronal chloride homeostasis and is rapidly regulated by the WNK signaling pathway

The paper shows that NKCC1 lateral diffusion is regulated by the WNK1-SPAK pathway, affecting chloride homeostasis in neurons.

Allosteric links between the hydrophilic N-terminus and transmembrane core of human Na+/H+ antiporter NHA2

This study identifies key residues in HsNHA2 that regulate ion selectivity and transport activity through structural and functional analysis.

The hidden intricacies of aquaporins: Remarkable details in a common structural scaffold

This study identifies key structural features of aquaporins through sequence, structural analysis, and simulations, revealing new insights into stability, selectivity, and mutation impact.

Characterization of aquaporin1b (AQP1b) mRNA in mud loach (Misgurnus mizolepis) in response to heavy metal and immunostimulant stimuli

The paper identifies AQP1b transcript variants and promoter regions in mud loach, showing differential modulation by heavy metals and immunostimulants.

Late adolescence mortality in mice with brain-specific deletion of the volume-regulated anion channel subunit LRRC8A

This study shows that brain-specific deletion of LRRC8A in mice leads to early mortality due to seizures, astrogliosis, and amino acid neurotransmitter dysregulation.

Regulation of the Molecular Shuttle Service: A Multiscale Model of Aquaporin 2 Recycling

The paper develops a multiscale computational model to understand the regulation of aquaporin 2 recycling and identifies cAMP compartmentalization as a key mechanism regulated by protein kinase A.

Investigating the effect of Ser256 phosphorylation on gating of aquaporin-2: Molecular Dynamics study

This study uses molecular dynamics simulations to investigate how phosphorylation of Ser256 in AQP2 affects its water permeability and gating mechanism, finding no direct effect on pore blocking.

Phosphoproteomic Identification of Vasopressin-Regulated Protein Kinases in Collecting Duct Cells

The paper identifies vasopressin-regulated protein kinases in collecting duct cells using phosphoproteomic analysis and finds six downstream kinases account for most phosphorylation sites.

The Structural Basis for Glycerol Permeation by human AQP7

This study determines the structure of human AQP7 and shows how its unique features enable glycerol transport.

Identification of compounds enhancing Aqp4 stop codon readthrough

The paper identifies Apigenin as a compound that enhances Aqp4 stop codon readthrough, potentially offering a therapeutic strategy for Alzheimer's disease.

Isolation and characterization of multi-protein complexes enriched in the K-Cl co-transporter 2 from brain plasma membranes

This study isolates and characterizes multi-protein complexes containing Kcc2 from brain plasma membranes, identifying novel interactors and phosphorylation sites that may regulate its function.

Protein kinase A catalytic-α and catalytic-β proteins have non-redundant functions

The paper identifies non-redundant functions of PKA-C and PKA-Cβ in renal collecting duct cells through phosphoproteomic analysis and shows distinct effects on AQP2 abundance.