Monoclonal and Polyclonal Antibodies Research

Conserved heavy/light contacts and germline preferences revealed by a large-scale analysis of natively paired human antibody sequences and structural data.

PairedAbNGS pools 58 single-cell bioprojects of natural paired human and mouse antibodies, revealing heavy/light V gene pairing biases beyond usage frequencies and conserved CDR3-FWR2 inter-chain contacts.

YAbS: The Antibody Society's antibody therapeutics database

YAbS catalogues over 2,900 commercially sponsored antibody therapeutics, from clinical entry since 2000 to approval, with milestone-date filtering for pipeline, trend and phase-length analyses; over 450 are openly accessible.

Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications

Over half of 614 commercial antibodies for 65 human neuroscience proteins failed a knockout-controlled assay, yet most targets had a well-performing antibody; recombinants performed best.

Efficient evolution of human antibodies from general protein language models and sequence information alone

Consensus likelihoods from general, unsupervised protein language models evolve seven human antibodies using only a wildtype sequence and <=20 tested variants, improving binding affinity up to 160-fold.