Scoliosis diagnosis and treatment

Biomechanical effects of load-carrying in adolescent idiopathic scoliosis: a subject-specific musculoskeletal modelling study

This study uses a subject-specific musculoskeletal model to examine how load magnitude, height, and side affect spinal loading and muscle forces in adolescent idiopathic scoliosis.

Serotonergic Control of Spine Morphology During Growth in Zebrafish

This study shows that serotonergic signaling is critical for spinal stability in zebrafish, with tph2 mutants exhibiting spinal curvature due to neuronal defects before visible curvature appears.

Influence of trunk posture on spinal loading and paraspinal muscle forces in adolescent idiopathic scoliosis: a subject-specific musculoskeletal modelling study

Active and Passive Mechanical Deficits Precede Spinal Curvature in a Zebrafish Model of Idiopathic Scoliosis

The paper identifies biomechanical deficits in zebrafish mutants that precede spinal curvature, linking urotensin signaling to axial tissue mechanics in scoliosis.

Pre-clinical models of idiopathic scoliosis implicate sex-specific roles for complement activity in modulating spinal curve severity

This study uses zebrafish models to show that complement components c3 and c5 modulate spinal curve severity in a sex-specific manner in idiopathic scoliosis.

Zebrafish armc9 mutant reveals a link between ARM-Type fold domain loss, inflammation, and spinal curvature

This study identifies a link between ARM-type fold domain loss in zebrafish Armc9, inflammation, and spinal curvature, suggesting a role in ciliary signaling and adolescent idiopathic scoliosis.

Identification of novel vertebral development factors through UK Biobank driven genetic and body imaging analysis reveals markers for back pain

The paper identifies three genes associated with vertebral variations and chronic pain using UK Biobank data and deep learning.

Whole Genome Sequencing in Adolescent Idiopathic Scoliosis Cohort Indicates Polygenic Disease Involving Multiple Biological Pathways

This study uses whole-genome sequencing to identify genetic variations and biological pathways associated with adolescent idiopathic scoliosis.

Association of genetic variation in COL11A1 with adolescent idiopathic scoliosis

This study identifies a genetic variant in COL11A1 associated with adolescent idiopathic scoliosis and proposes a molecular model involving Pax1, Col11a1, and Mmp3 in spinal chondrocytes.

A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis.

This study identifies a zebrafish mutation in PPP2R3B that causes kyphoscoliosis, mirroring human idiopathic scoliosis, with associated osteoporosis and mitochondrial abnormalities.

First Report of Evaluation of Variant rs11190870 nearby LBX1 Gene with Adolescent Idiopathic Scoliosis Susceptibility in a South-Asian Indian Population.

This study evaluates the association of variant rs11190870 with Adolescent Idiopathic Scoliosis in South-Asian Indian population and finds no significant association.

Diffusion MR imaging in the corticospinal tract of idiopathic scoliosis

The paper investigates diffusion MRI findings in the corticospinal tract of idiopathic scoliosis patients, finding abnormal fractional anisotropy asymmetry at the pons level.

The anti-fibrotic effects of RLN3 aggravated the pathogenesis of adolescent idiopathic scoliosis-a preliminary study

This study investigates the role of relaxin-3 in adolescent idiopathic scoliosis, finding increased plasma levels and anti-fibrotic effects that may worsen the condition.