Cardiovascular and exercise physiology

Age-Related Differences in Carbohydrate and Fat Oxidation Over 24 Hours and During Daily Activities in Humans

This study compares carbohydrate and fat oxidation in young and older adults over 24 hours and during daily activities, finding older adults oxidize more fat and less carbohydrate.

OpenCRS: an open-source regulated human cardiorespiratory model with large-scale calibration and global sensitivity analysis at rest and during exercise

OpenCRS is a cardiorespiratory model calibrated with global sensitivity analysis to identify influential parameters and mechanisms during rest and exercise.

Sympathetic activation and the force-frequency relationship in heart failure with reduced ejection fraction

This study examines the relationship between heart rate, sympathetic activation, and the force-frequency relationship in HFrEF patients and controls, finding a bidirectional link with optimal heart rate targets likely being individual.

Metabolic flexibility in response to resistance training plus photobiomodulation therapy in sedentary elderly women: a pilot study

This study evaluates the effects of resistance training plus photobiomodulation therapy on metabolic flexibility in sedentary elderly women, finding significant improvements in VO2max, carbohydrate oxidation, and energy expenditure compared to resistance training alone.

Metabolic Responses of Different Levels of Fitness

This study examines metabolic and physiological responses to exercise across four fitness levels in male cyclists, finding hierarchical patterns in performance and metabolic parameters.

Hemodynamic and Microvascular Adaptations to Aerobic Training Intensity Improve Maximal Oxygen Consumption

This paper compares high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on VO2max and microvascular adaptations, finding HIIT leads to greater VO2max improvement and distinct structural changes without angiogenesis.

Correlates of exercise hyperemia and muscle energetics in the human upper arm

This study investigates correlations between exercise hyperemia and muscle energetics in the human upper arm using MRI and MR spectroscopy, finding inverse correlations between hyperemic slope and acidification.

An Empirical Study on Quantifying Physical Energy Expenditure during High-intensity Exercise

This study develops a method to estimate physical energy expenditure during high-intensity exercise using non-invasive cardiovascular parameters and validates it against doubly labeled water measurements.

Cerebrovascular Responses to Static and Rhythmic Handgrip Exercises

This study compares cerebrovascular and systemic responses to static and rhythmic handgrip exercises at different intensities in healthy adults, finding that rhythmic exercise at moderate intensity induces greater cerebrovascular adaptations with lower perceived exertion.

Preservation of cerebral vascular and metabolic health with greater cardiorespiratory fitness in coronary artery disease

This study examines the relationship between cardiorespiratory fitness and cerebral vascular and metabolic health in CAD patients and healthy individuals, finding fitness improves vascular function and partially preserves metabolic function in CAD.

A Paradigm Shift in Walking, Sleep, and Exercise: Unique Effects on Blood Oxygen Saturation, Oxygen Diffusion, and Cellular Metabolism

The paper investigates how slow-paced exercises and sleep affect blood oxygen saturation and cellular metabolism, proposing metarobic theory to explain these effects and their health benefits.

Single-cell transcriptomic analyses unveil exercise-induced changes in murine skin vascular endothelial cells

The paper uses single-cell RNA sequencing to show exercise increases Zbtb16 expression and suppresses oxidative stress and metabolism in murine skin vascular endothelial cells.

Enhanced fitness relates to reduced cerebrovascular reactivity and perfusion in a sample of very healthy older adults

The paper examines the relationship between fitness, cerebral blood flow, and cerebrovascular reactivity in older adults, finding that higher fitness is associated with reduced cerebrovascular reactivity and altered hemodynamic responses.