Nucleation limited assembly and polarized growth of a de novo-designed allosterically modulatable protein filament
Hao Shen, Eric M. Lynch, Chenyang Shi, Joseph L. Watson, Yulai Liu, Ke‐Jia Wu, Hua Bai, Chan Johng Kim, William Sheffler, Emmanuel Derivery, James J De Yoreo, Justin M. Kollman, David A. Baker
This paper designs a tunable protein filament that assembles in response to a peptide ligand and demonstrates its polarized growth and nucleation mechanisms.
bioRxiv · Sep 20, 2024 · PreprintBioengineering