Neuroscience of respiration and sleep

Role of synaptic inhibition in the coupling of the respiratory rhythms that underlie eupnea and sigh behaviors

The paper investigates the neural mechanisms coupling eupnea and sigh rhythms in the preBotzinger Complex, finding that synaptic inhibition does not enforce their temporal coordination.

Network Synchronization and Synchrony Propagation:Emergent Elements of Inspiration

The paper investigates preBotC network dynamics under rhythmic and nonrhythmic conditions, revealing synchronization mechanisms and their role in respiratory rhythmogenesis.

Identification of a novel breathing circuit that controls pain and anxiety

This study identifies a novel neural circuit involving PBLOprm1 neurons that regulates breathing, pain, and anxiety by linking limbic signals to respiratory control.

Evaluating the burstlet theory of inspiratory rhythm and pattern generation

The paper tests burstlet theory by analyzing preBotC neuron activity and hypoglossal nerve discharge to determine if burstlets are the fundamental oscillator for inspiratory rhythm.

Inspiratory rhythmogenic activity is burst-independent and opioid-sensitive

The paper investigates how respiratory rhythm is generated in the preBotzinger Complex and shows that opioid receptors modulate burstlet frequency, independent of motor output bursts.

Insights into the dynamic control of breathing revealed through cell-type-specific responses to substance P

The paper investigates how substance P modulates breathing dynamics in the mouse preBötzinger complex by enhancing recurrent excitation between breaths, revealing a framework for dynamic control of breathing.

Adrenergic C1 neurons are part of the circuitry that recruits active expiration in response to hypoxia

The paper identifies C1 neurons as part of the circuitry that drives active expiration during hypoxia by projecting to the pFRG and modulating its activity.

Effects of persistent sodium current blockade in respiratory circuits depend on the pharmacological mechanism of action and network dynamics

This study uses computational simulations to show that different pharmacological mechanisms of sodium current blockade can lead to distinct effects on respiratory circuits, challenging the assumption that all blockers act equivalently.

Robustness of respiratory rhythm generation across dynamic regimes

This study shows that respiratory rhythm generation remains robust across different dynamic regimes of intrinsic pacemaker properties in a computational model of the respiratory network.

Disordered breathing in a mouse model of Dravet syndrome

This study investigates respiratory dysfunction in a mouse model of Dravet syndrome, finding that SCN1a mutations disrupt brainstem respiratory control.

Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model

The paper re-examines the roles of INaP and ICAN in respiratory rhythm generation using a new computational model, finding that ICAN affects amplitude while INaP drives rhythm.

Respiratory gas levels interact to control ventilatory motor patterns in isolated locust ganglia

The paper investigates how respiratory gas levels interact to control ventilatory motor patterns in isolated locust ganglia, finding that hypoxia and hypercapnia both increase ventilation rate with hypercapnia being more potent.

Dbx1 pre-Bötzinger complex interneurons comprise the core inspiratory oscillator for breathing in adult mice

The paper identifies Dbx1 pre-Bötzinger complex neurons as essential for generating inspiratory rhythms in adult mice through optogenetic manipulation.

HIF-2α is essential for carotid body development and function

This study shows HIF-2α is essential for the development and function of carotid body glomus cells, which are critical for hypoxic ventilatory responses and related physiological processes.

Computational model of brainstem circuit for state dependent control of hypoglossal motoneurons

The paper develops a computational model of brainstem circuits to study how noradrenergic and serotonergic drives affect hypoglossal motoneurons during REM sleep, aligning with in vivo data.

Astrocytes release prostaglandin E2 to modify respiratory network activity

The paper shows that astrocytes in the pFRG/RTN release PGE2, which modifies respiratory network activity by altering calcium oscillation frequency during hypercapnia.