Neuroscience of respiration and sleep

Sex and APOE Genotype Influence Respiratory Function Under Hypoxic and Hypoxic-Hypercapnic Conditions

This study shows that sex and APOE genotype affect breathing during hypoxia, with female mice showing impaired recovery.

A novel preparation of the entire isolated CNS unveils the modulatory influences of supra-pontine structures on brainstem and spinal networks.

This study introduces a novel in vitro preparation of the isolated CNS to investigate how supra-pontine structures modulate brainstem and spinal networks involved in respiration and locomotion.

Predictions and experimental tests of a new biophysical model of the mammalian respiratory oscillator

The paper tests and confirms three predictions of a biophysical model of the mammalian respiratory oscillator using optogenetic and pharmacological manipulations in neonatal mouse slices.

Sigh breathing rhythm depends on intracellular calcium oscillations in a population of inspiratory rhythmogenic preBötzinger complex neurons in mice

The paper shows that a single population of preBötzinger complex neurons generates both inspiratory and sigh breathing rhythms through distinct cellular mechanisms, without requiring gliotransmission or synaptic inhibition.

Putting the theory into 'burstlet theory': A biophysical model of bursts and burstlets in the respiratory preBötzinger complex

The paper develops a biophysical model explaining respiratory rhythm generation in the preBotC by integrating calcium dynamics and burstlet theory.

A neuromodulatory model for determining the effect of emotion-respiration-cognition coupling on the time-to-respond

The paper models how emotion, respiration, and cognition interact to affect reaction time by integrating neural, neuromechanical, and neuromodulatory systems.

The pre-Bötzinger complex is necessary for the expression of post-inspiration

This study investigates the role of the pre-Botzinger complex in respiratory motor patterns by inactivating it in a rat brainstem preparation, showing its necessity for post-inspiration and inspiratory activity.

The Carotid Body Detects Circulating Tumor Necrosis Factor-Alpha to Activate a Sympathetic Anti-Inflammatory Reflex

This study shows that the carotid body detects circulating TNF-α and activates a sympathetic anti-inflammatory reflex in rats.

Transcriptomes of Electrophysiologically Recorded Dbx1-derived Inspiratory Neurons of the preBötzinger Complex in Neonatal Mice

The paper identifies differential gene expression between two types of Dbx1-derived neurons in the preBötzinger complex, linking specific genes to their functional roles in respiratory rhythm generation.

The influence of the respiratory cycle on reaction times in sensory-cognitive paradigms

This study investigates how the respiratory cycle influences reaction times in sensory-cognitive tasks, finding significant covariation between reaction times and respiratory states.

Breathing Behaviors in Common Marmoset (Callithrix jacchus)

This study characterizes breathing behaviors in common marmosets under different O2 and CO2 conditions and develops an analysis toolkit for respiratory activity.

Phase- and State-Dependent Modulation of Breathing Pattern by preBötzinger Complex Somatostatin Expressing Neurons

This paper investigates how preBotC SST+ neurons modulate breathing patterns in different states and frequencies, revealing phase- and state-dependent responses that challenge existing models.

Molecular, anatomical, and functional organization of lung interoceptors

The paper presents a transcriptomic atlas of mouse lung interoceptors, identifying 10 molecular subtypes with distinct functional roles in breathing control.

Neural pathways linking hypoxia with pectoral fin movements in Danio rerio

The paper identifies neural pathways in zebrafish larvae that link hypoxia detection by skin-resident neuroendocrine cells to increased pectoral fin movements and heart activity.

Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm generating network

This study identifies two mechanisms by which opioid activation disrupts inspiratory rhythm generation in the preBotC, leading to respiratory depression.

Upregulation of breathing rate during running exercise by central locomotor circuits

This study identifies neural circuits in mice that mediate increased breathing during running exercise by linking locomotor regions to respiratory control centers.

Neural basis of opioid-induced respiratory depression and its rescue

This study identifies PBLOprm1 neurons as critical for opioid-induced respiratory depression and shows their activation can rescue respiratory rhythms.

Kv1.1 subunits localize to cardiorespiratory brain networks in mice where their absence induces astrogliosis and microgliosis

The paper maps Kv1.1 protein expression in cardiorespiratory brain regions of mice and finds gliosis in Kcna1-/- mice, suggesting seizure-related brain injury may contribute to respiratory dysfunction.

The deep and slow breathing characterizing rest favors brain respiratory-drive

The paper shows that during quiet waking, the brain's respiratory drive is optimal due to a specific respiration regime involving deep and prolonged inspiration.

Heartbeats entrain breathing via baroreceptor-mediated modulation of expiratory activity

The paper investigates how heartbeats influence breathing through baroreceptor-mediated modulation of expiratory activity in both humans and rodent models.

A novel reticular oscillator in the brainstem synchronizes neonatal crying with breathing

The paper identifies a brainstem oscillator in neonatal mice that coordinates crying with breathing by structuring rhythmically-timed vocalizations.

Reciprocal connectivity of the periaqueductal gray with the ponto-medullary respiratory network in rat.

This study maps reciprocal connectivity between the periaqueductal gray (PAG) and brainstem respiratory nuclei in rats, revealing distinct patterns of connectivity with the Kolliker-Fuse nucleus and limited connections with the Botzinger complex.

Microcircuit synchronization and heavy tailed synaptic weight distribution in preBötzinger Complex contribute to generation of breathing rhythm

The paper uses computational models to show that directed Erdős-Rényi graphs and lognormal synaptic weights in the preBötzinger Complex generate robust breathing rhythms through synchronization and input convergence.

Forebrain projection neurons target functionally diverse respiratory control areas in the midbrain, pons and medulla oblongata

The paper maps descending forebrain projections to midbrain, pons, and medulla oblongata respiratory control nuclei, revealing distinct cortical inputs to specific nuclei involved in breathing and orofacial behaviors.

Independent respiratory and locomotor rhythms in running mice

This study shows that respiratory rate in running mice increases to a fixed value during trotting and further increases during gallop, without coordination between breaths and strides.

Wt1 positive neurons in the hindbrain are essential for respiration

This study identifies Wt1-positive dB4 neurons in the hindbrain essential for respiration and shows their developmental role in regulating breathing.

Connexin26 mediates CO2-dependent regulation of breathing via glial cells of the medulla oblongata

The paper shows that CO2-binding to Cx26 in glial cells of the medulla oblongata contributes significantly to ventilatory responses to CO2.

Vascular control of the CO2/H+ dependent drive to breathe

The paper identifies P2Y2 receptors in RTN vascular smooth muscle cells as essential for CO2/H+ chemoreception and respiratory behavior in mice.

Monosynaptic projections to excitatory and inhibitory preBotzinger Complex neurons

This study identifies monosynaptic projections to excitatory and inhibitory preBotzinger Complex neurons from brainstem and suprapontine regions using rabies tracing.

Functional convergence of autonomic and sensorimotor processing in the lateral cerebellum

This study investigates how Purkinje cell activity in the cerebellum coordinates autonomic and sensorimotor behaviors during respiration, showing context- and phase-dependent effects.