Tamoxifen Targets Wisp2 to Impair Subcutaneous Adipocyte Progenitor Self-Renewal and Adipogenic Differentiation
Nisha S. Thomas, Barbara Mensah Sankofi, Haoning Howard Cen, Malika Sekhri, Stevi J. Murguia, Mathew Amprayil Cherian, Michael B. Stout, Benjamin F. Miller, Michael C. Rudolph, Elizabeth A. Wellberg
This study shows tamoxifen reduces subcutaneous adipocyte progenitor self-renewal and adipogenesis by suppressing Wisp2, linking endocrine therapy to metabolic risks like T2D.
Communications Biology · Oct 30, 2026Peer-reviewedCell Biology