Topic · Obstetrics and Gynecology · Medicine
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
7 papers
Guilherme de Moraes Nobrega, Eliza R. McColl, Arthur Antolini‐Tavares, Renato T. Souza, José Guilherme Cecatti, Maria Laura Costa, Indira U. Mysorekar
This study examines placental changes in SARS-CoV-2 infected pregnancies, finding localized oxidative stress and DNA damage without overall senescence differences.
American Journal of Reproductive Immunology · Dec 30, 2024Peer-reviewedMicrobiology
Nataly Stylianou, Ismail Sebina, Nicholas Matigian, James H. Monkman, Hadeel Doehler, Joan Röhl, Mark C. Allenby, Andy Nam, Liuliu Pan, Anja Rockstroh, Habib Sadeghirad, Kimberly Chung, Thais Sobanski, Kenneth John O'Byrne, Ana Clara Simoes Florido Almeida, , Arutha Kulasinghe
This study uses spatial transcriptomics to identify placental dysfunction signatures in SARS-CoV-2 infected pregnancies, revealing altered gene expression related to hypoxia, oxidative stress, and preeclampsia-like pathways.
Clinical & Translational Immunology · Jan 1, 2024Peer-reviewedDevelopmental Biology
Mauricio Montaño, Andrea R. Victor, Darren Karl Griffin, Tommy Duong, Nathalie Bolduc, Andrew A. Farmer, Vidur Garg, Anna‐Katerina Hadjantonakis, Alison Coates, Frank L. Barnes, Christo Zouves, Warner C. Greene, Manuel Viotti
This study shows SARS-CoV-2 can infect human embryos, specifically trophectoderm cells in blastocysts, with potential implications for reproductive health.
Scientific Reports · Sep 14, 2022Peer-reviewedDevelopmental Biology
Flávia Bessi Constantino, Sarah Santiloni Cury, Célia Regina Nogueira, Robson Francisco Carvalho, Luís Antônio Justulin
The paper identifies non-canonical mediators of SARS-CoV-2 infection in placental cells through transcriptomic analysis.
Frontiers in Molecular Biosciences · Nov 8, 2021Peer-reviewedDevelopmental Biology
Jyoti Goad, Joshua D. Rudolph, Aleksandar Rajkovic
The paper investigates SARS-CoV2 receptor expression in female reproductive tissues and finds no significant ACE2 or TMPRSS2 expression, suggesting low susceptibility to infection.
PLoS ONE · Dec 14, 2020Peer-reviewedGenetics
Roger Piqué-Regi, Roberto J. Romero, Adi Laurentiu Tarca, Francesca Luca, Yi Xu, Adnan Alazizi, Yaozhu Leng, Chaur‐Dong Hsu, Nardhy Gomez‐Lopez
The paper investigates ACE2 and TMPRSS2 expression in human placenta across pregnancy stages and finds negligible co-expression, suggesting SARS-CoV-2 is unlikely to infect placenta via canonical entry mediators.
eLife · Jul 13, 2020Peer-reviewedGenomics
Mengmeng Li, Liang Chen, Jingxiao Zhang, Chenglong Xiong, Xiangjie Li
The paper investigates ACE2 expression in maternal-fetal interface and fetal organs using single-cell transcriptomics but was withdrawn due to insufficient analysis of ACE2 and TMPRSS2.
PLoS ONE · Apr 16, 2020Peer-reviewedGenomics